CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041218
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat and FYVE domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 Wdfy3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
581RCAHNIVKYPQCRQHubiquitination[1]
730GCFSDLRKISAVNVFubiquitination[1]
957LNCGAWDKKLLKQYRubiquitination[1]
2283SSGFGLSKLTGSRRNubiquitination[1]
2326DLVDTQYKEYQERQQacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; WD repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3526 AA 
Protein Sequence
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 60
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 120
SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAG GGAQNELPLA 180
ERRGLLQKAF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM 240
TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL 300
LDDFRIWQGY NFLCDLLLRL EQGKEAECRD ALKDLVSLVT SLTTYGVSEL KPAGVTTGAP 360
FLLPGFAVPQ PAGKGHSVRN IQAFAVLQNA FLKAKTNFLA QIILDAITNI YMADNANYFI 420
LESQHTLSQF AEKISKLPEV QNKYFEMLEF VVFSLNYIPC KELISVSILL KSSSSYHCSI 480
IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPAQALNEQ GDSRNNSSVE 540
DQKHLALLVM EALTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP 600
NGEDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG FVYITSLLVA 660
MERSLSSPPK NGWEKVSQSQ VLELLHTVFC TLTAALRYEP ANSHFFKTEI QYEKLADAVR 720
FLGCFSDLRK ISAVNVFPSN TQPFQRLLEE GAVSVDSVSP TLRHCSKLFI YLYKVATDSF 780
DSHAEQIPPC LTSESSLPSP WGTPALSRKR HAFHCVSTPP VYPAKNVTDL KLQVTSSPLQ 840
SSDAVIIHPG AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL 900
HARLLQRCGA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL 960
KQYRVHKPSS LSFEPEMRSS VITSLEGLGS DNVFSSHEDN HYRISKSLVK SAEGSTVPLT 1020
RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT SLEGFGCLFL PSLAPHNAPT NNTVTTGLTD 1080
GAVVSGMGSG ERFFPPPSGL SYSCWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA 1140
IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELVVE GQWHHLALLM 1200
SRGMLKNSTA ALYLDGQLVS TVKLHYVHST PGGSGSANPP VLSTVYAYVG TPPAQRQIAS 1260
LVWRLGPTHF LEEVLPPSSV TTIYELGPNY VGSFQAVCVP CKDAKSEGVT PSPVSLVAEE 1320
KVSFGLYALS VSSLTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLVH NAAGHLNGPA 1380
RTIGAALIGY LGVRTFVPKP VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS 1440
NPLASKEMER IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD 1500
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ 1560
PTIAAISNVL SFLLQGFPNS NDLLRFGQFI SSTLPTFAVC EKFVVMEINN EEKPDPGAEE 1620
EFGGLVSANL ILLRNRLLDI LLKLVYTSKE KTNINLQACE ELVRTLGFDW IMMFMEEHLH 1680
PTTVTAAMRI LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR 1740
STVREINRDA CHFPGFLVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVTS 1800
SRCKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTESA FLLLGMLRSM LNSPWQSEEE 1860
GSWLREYPVT LMQFFRYLYH NVPDLASMWL SPDFLCALAA TVFPFNIRPY SEMVTDLDDE 1920
VGSPAEEFKA FAADTGMNRS QSEYCNVGTK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS 1980
KQTPLIDLLL EASPERSTRT QQKEFQTHVL DSVMDHLLAA DVLLGEDASL PITSGGSYQV 2040
LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL 2100
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHAGSVEGFG 2160
LEAEARMTTW HIMIPSDIEP DGGYSQDISE GRQLLIKAVN RVWTELIHSK KQVLEELFKV 2220
SLPVNDRGHV DIALARPLIE EAGLKCWQNH LAHEKKCISR GEALVPTTQS KLSRVSSGFG 2280
LSKLTGSRRN RKESGLHKHS PSPQEISQWM FTHIAVVRDL VDTQYKEYQE RQQNALKYVT 2340
EEWCQIECEL LRERGLWGPP IGSHLDKWML EMTEGPCRMR KKMVRNDMFY NHYPYVPETE 2400
QEASVGSEIP SKQPEPPDDV IAQKKPARYR RAISYDSKEY YLRLASGNPA IVQDAIVESS 2460
EGEATQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE TQEQLQDQIA ESGSIEEEEK 2520
TDNATLLRLL EEGEKIQHMY RCARVQGLDT SEGLLLFGKE HFYVIDGFTM TATREIRDIE 2580
TLPPNMHEPI IPRGARQGPS QLKRTCSIFA YEDIKEVHKR RYLLQPIAVE VFSGDGRNYL 2640
LAFQKGIRNK VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ GSGLLSTLVG EKSVTQRWER 2700
GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILSDYDSEE VDLTNPKTFR NLAKPMGAQT 2760
DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL VRMEPFTQIF LRLQGGHFDL 2820
ADRMFHSVRE AWYSASKHNM ADVKELIPEF FYLPEFLFNS NNFDLGCKQN GTKLGDVILP 2880
PWAKGDPREF IRVHREALEC DYVSAHLHEW IDLIFGYKQQ GPAAVEAVNV FHHLFYEGQV 2940
DIYNINDPLK ETATIGFINN FGQIPKQLFK KPHPPKRVRS RLNGDNIGIS VPPGATSDKI 3000
FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV LIPPAWNKTF AWGYADLSCR 3060
LGTYESDKAV TVYECLSEWG QILCAVCPNP KLVITGGTST VVCVWEMGTS KEKAKPLTLK 3120
QALLGHTDTV TCATASLAYH IIVSGSRDRT CIIWDLNKLS FLTQLRGHRA PVSALCINEL 3180
TGDIVSCAGT YIHVWSINGN PIVSVNTFTG RSQQIVCCCM SEMNEWDTQN VIVTGHSDGV 3240
VRFWRMEFLQ VPETPAPEPV EDLEMQEGCP EAQIGQQAQD DDSSDSETEE PSVSQDPKDT 3300
SSQPSSTSHR PRAASCRATA TWCTDSGSDD SRRWSDQLSL DEKDGFIFVN YSEGQTRAHL 3360
QGPLAHPHPN PIEARSYSRL KPGYRWERQL VFRSKLTMHT AFDRKDNTHP AEVTALGVSK 3420
DHSRILVGDS RGRVFSWSVS DQPGRSAADH WVKDEGGDSC SGCSVRFSLT ERRHHCRNCG 3480
QLFCQKCSRF QSEIKRLKIS SPVRVCQNCY YSLQHERGAE DGPRNC 3526 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0019898; C:extrinsic to membrane; ISA:MGI.
 GO:0005635; C:nuclear envelope; ISA:MGI.
 GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR000409; BEACH_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02138; Beach
 PF01363; FYVE
 PF00400; WD40 
SMART
 SM01026; Beach
 SM00064; FYVE
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION
 PS50178; ZF_FYVE 
PRINTS