CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006288
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear hormone receptor FTZ-F1 
Protein Synonyms/Alias
 FTZ-F1 alpha; Nuclear receptor subfamily 5 group A member 3 
Gene Name
 ftz-f1 
Gene Synonyms/Alias
 NR5A3; CG4059 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
418AYPNMNIKQEIQIPQsumoylation[1]
Reference
 [1] The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.
 Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA.
 Mol Cell Biol. 2005 Mar;25(5):1879-90. [PMID: 15713642] 
Functional Description
 Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'- YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand. 
Sequence Annotation
 DNA_BIND 505 580 Nuclear receptor.
 ZN_FING 508 528 NR C4-type.
 ZN_FING 544 568 NR C4-type.
 REGION 834 876 Ligand-binding (Potential).  
Keyword
 3D-structure; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1027 AA 
Protein Sequence
MLLEMDQQQA TVQFISSLNI SPFSMQLEQQ QQPSSPALAA GGNSSNNAAS GSNNNSASGN 60
NTSSSSNNNN NNNNDNDAHV LTKFEHEYNA YTLQLAGGGG SGSGNQQHHS NHSNHGNHHQ 120
QQQQQQQQQQ QHQQQQQEHY QQQQQQNIAN NANQFNSSSY SYIYNFDSQY IFPTGYQDTT 180
SSHSQQSGGG GGGGGGNLLN GSSGGSSAGG GYMLLPQAAS SSGNNGNPNA GHMSSGSVGN 240
GSGGAGNGGA GGNSGPGNPM GGTSATPGHG GEVIDFKHLF EELCPVCGDK VSGYHYGLLT 300
CESCKGFFKR TVQNKKVYTC VAERSCHIDK TQRKRCPYCR FQKCLEVGMK LEAVRADRMR 360
GGRNKFGPMY KRDRARKLQV MRQRQLALQA LRNSMGPDIK PTPISPGYQQ AYPNMNIKQE 420
IQIPQVSSLT QSPDSSPSPI AIALGQVNAS TGGVIATPMN AGTGGSGGGG LNGPSSVGNG 480
NSSNGSSNGN NNSSTGNGTS GGGGGNNAGG GGGGTNSNDG LHRNGGNGNS SCHEAGIGSL 540
QNTADSKLCF DSGTHPSSTA DALIEPLRVS PMIREFVQSI DDREWQTQLF ALLQKQTYNQ 600
VEVDLFELMC KVLDQNLFSQ VDWARNTVFF KDLKVDDQMK LLQHSWSDML VLDHLHHRIH 660
NGLPDETQLN NGQVFNLMSL GLLGVPQLGD YFNELQNKLQ DLKFDMGDYV CMKFLILLNP 720
SVRGIVNRKT VSEGHDNVQA ALLDYTLTCY PSVNDKFRGL VNILPEIHAM AVRGEDHLYT 780
KHCAGSAPTQ TLLMEMLHAK RKG 803 
Gene Ontology
 GO:0005737; C:cytoplasm; NAS:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; NAS:FlyBase.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:FlyBase.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008219; P:cell death; TAS:FlyBase.
 GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
 GO:0035626; P:juvenile hormone mediated signaling pathway; IMP:FlyBase.
 GO:0042048; P:olfactory behavior; IMP:FlyBase.
 GO:0007365; P:periodic partitioning; IMP:FlyBase.
 GO:0035074; P:pupation; IMP:FlyBase.
 GO:0040034; P:regulation of development, heterochronic; TAS:FlyBase.
 GO:0035075; P:response to ecdysone; TAS:FlyBase. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.