CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008589
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ER membrane protein complex subunit 4 
Protein Synonyms/Alias
  
Gene Name
 EMC4 
Gene Synonyms/Alias
 YGL231C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
48SKGNVTRKQQDATSQubiquitination[1]
125FSTRSAFKPVLGNKAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). 
Sequence Annotation
  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 190 AA 
Protein Sequence
MSEQEPYEWA KHLLDTKYIE KYNIQNSNTL PSPPGFEGNS SKGNVTRKQQ DATSQTTSLA 60
QKNQITVLQV QKAWQIALQP AKSIPMNIFM SYMSGTSLQI IPIMTALMLL SGPIKAIFST 120
RSAFKPVLGN KATQSQVQTA MFMYIVFQGV LMYIGYRKLN SMGLIPNAKG DWLPWERIAH 180
YNNGLQWFSD 190 
Gene Ontology
 GO:0072546; C:ER membrane protein complex; IDA:SGD.
 GO:0034975; P:protein folding in endoplasmic reticulum; IGI:SGD. 
Interpro
 IPR009445; DUF1077_TMEM85. 
Pfam
 PF06417; DUF1077 
SMART
  
PROSITE
  
PRINTS