CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 StAR-related lipid transfer protein 4 
Protein Synonyms/Alias
 START domain-containing protein 4; StARD4 
Gene Name
 STARD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13DVASFATKLKNTLIQubiquitination[1, 2, 3]
15ASFATKLKNTLIQYHubiquitination[4]
28YHSIEEDKWRVAKKTubiquitination[3, 5]
34DKWRVAKKTKDVTVWubiquitination[3, 5]
36WRVAKKTKDVTVWRKubiquitination[3, 4, 5]
43KDVTVWRKPSEEFNGubiquitination[4, 6]
141ISLDWDEKRPEFVRGubiquitination[4]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). 
Sequence Annotation
 DOMAIN 1 205 START.  
Keyword
 Complete proteome; Lipid transport; Lipid-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 205 AA 
Protein Sequence
MEGLSDVASF ATKLKNTLIQ YHSIEEDKWR VAKKTKDVTV WRKPSEEFNG YLYKAQGVID 60
DLVYSIIDHI RPGPCRLDWD SLMTSLDILE NFEENCCVMR YTTAGQLWNI ISPREFVDFS 120
YTVGYKEGLL SCGISLDWDE KRPEFVRGYN HPCGWFCVPL KDNPNQSLLT GYIQTDLRGM 180
IPQSAVDTAM ASTLTNFYGD LRKAL 205 
Gene Ontology
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW. 
Interpro
 IPR023393; START-like_dom.
 IPR002913; START_lipid-bd_dom. 
Pfam
 PF01852; START 
SMART
  
PROSITE
 PS50848; START 
PRINTS