UniProt Accession

 SC22B_MOUSE; O08547; Q91VU3 

Genbank Protein ID

 U91538; AK017237; AK034973; AK037918; AK088514; AK089928; BC009024 

Genbank Nucleotide ID

 AAC53130.1; BAB30646.1; BAC28899.1; BAC29901.1; BAC40397.1; BAC40999.1; AAH09024.1 

Protein Name

 Vesicle-trafficking protein SEC22b 

Protein Synonyms/Alias

 ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; mSec22b 

Gene Name

 Sec22b 

Gene Synonyms/Alias

 Sec22l1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	QQYQSQAKQLFRKLN	acetylation	[1]
38	QQYQSQAKQLFRKLN	ubiquitination	[2]
82	CEAAFPKKLAFAYLE	ubiquitination	[2]
101	EFDEQHGKKVPTVSR	ubiquitination	[2]
102	FDEQHGKKVPTVSRP	ubiquitination	[2]
169	ALSALDSKANNLSSL	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. 

Sequence Annotation

 DOMAIN 6 119 Longin.
 DOMAIN 134 194 v-SNARE coiled-coil homology.
 MOD_RES 38 38 N6-acetyllysine (By similarity).
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 140 140 Phosphothreonine (By similarity).
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 177 177 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR011012; Longin-like_dom.
 IPR010908; Longin_dom.
 IPR001388; Synaptobrevin. 

Pfam

 PF13774; Longin
 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS50859; LONGIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.