CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorbin and SH3 domain-containing protein 1 
Protein Synonyms/Alias
 Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP 
Gene Name
 SORBS1 
Gene Synonyms/Alias
 KIAA0894; KIAA1296; SH3D5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1130ESGQYERKAERGAGEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). 
Sequence Annotation
 DOMAIN 366 469 SoHo.
 DOMAIN 793 852 SH3 1.
 DOMAIN 867 928 SH3 2.
 DOMAIN 1231 1292 SH3 3.
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 134 134 Phosphotyrosine (By similarity).
 MOD_RES 349 349 Phosphothreonine (By similarity).
 MOD_RES 472 472 Phosphoserine.
 MOD_RES 481 481 Phosphoserine.
 MOD_RES 497 497 Phosphothreonine (By similarity).
 MOD_RES 536 536 Phosphotyrosine; by ABL1 (By similarity).
 MOD_RES 556 556 Phosphoserine (By similarity).
 MOD_RES 640 640 Phosphoserine (By similarity).
 MOD_RES 654 654 Phosphotyrosine; by ABL1 (By similarity).
 MOD_RES 665 665 Phosphoserine.
 MOD_RES 862 862 Phosphothreonine.
 MOD_RES 945 945 Phosphoserine.
 MOD_RES 1240 1240 Phosphotyrosine; by ABL1 (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1292 AA 
Protein Sequence
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 60
LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 120
NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT SSSAAQPEVI VVPLYLVNTD RGQEGTARPP 180
TPLGPLGCVP TIPATASAAS PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS 240
FSPPPPLVPP APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 300
YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS PGKAIEKRAK 360
DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK QIHKLNRDTP EENPYFPTYK 420
FPELPEIQQT SEEDNPYTPT YQFPASTPSP KSEDDDSDLY SPRYSFSEDT KSPLSVPRSK 480
SEMSYIDGEK VVKRSATLPL PARSSSLKSS SERNDWEPPD KKVDTRKYRA EPKSIYEYQP 540
GKSSVLTNEK MSRDISPEEI DLKNEPWYKF FSELEFGKPP PKKIWDYTPG DCSILPREDR 600
KTNLDKDLSL CQTELEADLE KMETLNKAPS ANVPQSSAIS PTPEISSETP GYIYSSNFHA 660
VKRESDGAPG DLTSLENERQ IYKSVLEGGD IPLQGLSGLK RPSSSASTKD SESPRHFIPA 720
DYLESTEEFI RRRHDDKEKL LADQRRLKRE QEEADIAARR HTGVIPTHHQ FITNERFGDL 780
LNIDDTAKRK SGSEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG 840
IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV 900
DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA TASPQFSSHS 960
KLITPAPSSL PHSRRALSPE MHAVTSEWIS LTVGVPGRRS LALTPPLPPL PEASIYNTDH 1020
LALSPRASPS LSLSLPHLSW SDRPTPRSVA SPLALPSPHK TYSLAPTSQA SLHMNGDGGV 1080
HTPSSGIHQD SFLQLPLGSS DSVISQLSDA FSSQSKRQPW REESGQYERK AERGAGERGP 1140
GGPKISKKSC LKPSDVVRCL STEQRLSDLN TPEESRPGKP LGSAFPGSEA EQTERHRGGE 1200
QAGRKAARRG GSQQPQAQQR RVTPDRSQTS QDLFSYQALY SYIPQNDDEL ELRDGDIVDV 1260
MEKCDDGWFV GTSRRTKQFG TFPGNYVKPL YL 1292 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005829; C:cytosol; ISS:BHF-UCL.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0045121; C:membrane raft; ISS:UniProtKB.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0001725; C:stress fiber; ISS:UniProtKB.
 GO:0005915; C:zonula adherens; TAS:ProtInc.
 GO:0003779; F:actin binding; TAS:ProtInc.
 GO:0005158; F:insulin receptor binding; IDA:UniProtKB.
 GO:0005070; F:SH3/SH2 adaptor activity; ISS:BHF-UCL.
 GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.
 GO:0015758; P:glucose transport; ISS:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
 GO:0006936; P:muscle contraction; TAS:Reactome.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; ISS:BHF-UCL.
 GO:0046326; P:positive regulation of glucose import; ISS:BHF-UCL.
 GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:BHF-UCL.
 GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:BHF-UCL.
 GO:0043149; P:stress fiber assembly; ISS:UniProtKB. 
Interpro
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR003127; Sorb. 
Pfam
 PF00018; SH3_1
 PF07653; SH3_2
 PF02208; Sorb 
SMART
 SM00326; SH3
 SM00459; Sorb 
PROSITE
 PS50002; SH3
 PS50831; SOHO 
PRINTS