UniProt Accession

 ZNF3_HUMAN; P17036; D6W5U0; P13683; Q9HBR4; Q9NNX8; Q9NXJ1; Q9UC15; Q9UC16 

Genbank Protein ID

 AF217988; AF193057; AK000223; AK297625; CH471091; CH471091; CH471091; BC011887; BC013603; X60153; X52356; X07290 

Genbank Nucleotide ID

 AAG17231.1; AAG22485.1; BAA91019.1; BAH12633.1; EAW76605.1; EAW76606.1; EAW76608.1; AAH11887.2; AAH13603.2; CAB94195.1; CAA36582.1; CAA30269.1 

Protein Name

 Zinc finger protein 3 

Protein Synonyms/Alias

 Zinc finger protein HF.12; Zinc finger protein HZF3.1; Zinc finger protein KOX25 

Gene Name

 ZNF3 

Gene Synonyms/Alias

 KOX25 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
118	VLLGRFQKDISQGLK	ubiquitination	[1, 2]
137	YEREVSLKRPLGNSP	ubiquitination	[2]
173	PRGERSEKYNDFGNS	ubiquitination	[2]
310	QRIHTGEKPYACNEC	ubiquitination	[2]
319	YACNECGKAFSRSST	ubiquitination	[2]
403	YECSECGKAFRYSSA	ubiquitination	[3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in cell differentiation and/or proliferation. 

Sequence Annotation

 DOMAIN 51 123 KRAB.
 ZN_FING 200 222 C2H2-type 1.
 ZN_FING 228 250 C2H2-type 2.
 ZN_FING 256 278 C2H2-type 3.
 ZN_FING 284 306 C2H2-type 4.
 ZN_FING 312 334 C2H2-type 5.
 ZN_FING 340 362 C2H2-type 6.
 ZN_FING 368 390 C2H2-type 7.
 ZN_FING 396 418 C2H2-type 8.
 MOD_RES 143 143 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 446 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0045321; P:leukocyte activation; NAS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF01352; KRAB 

SMART

 SM00349; KRAB
 SM00355; ZnF_C2H2 

PROSITE

 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS