UniProt Accession

 MT21D_HUMAN; Q9H867; B7ZLA3; B7ZLA4; Q2M2X3; Q86T12 

Genbank Protein ID

 AK023982; AK129564; BX247997; AL109758; BC027585; BC105118; BC143673; BC143674 

Genbank Nucleotide ID

 BAB14752.1; BAC85183.1; CAD62329.1; AAI05119.1; AAI43674.1; AAI43675.1 

Protein Name

 Protein-lysine methyltransferase METTL21D 

Protein Synonyms/Alias

 Methyltransferase-like protein 21D; VCP lysine methyltransferase; VCP-KMT 

Gene Name

 METTL21D 

Gene Synonyms/Alias

 C14orf138 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	KMNINMNKHLVTGSV	ubiquitination	[1]
122	VTGSVQAKGGRNRRL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0016279; F:protein-lysine N-methyltransferase activity; IDA:UniProtKB.
 GO:0018023; P:peptidyl-lysine trimethylation; IDA:UniProtKB. 

Interpro

 IPR019410; Nicotinamide_N-MeTfrase-like. 

Pfam

 PF10294; Methyltransf_16 

SMART

  

PROSITE

  

PRINTS