CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041666
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clusterin 
Protein Synonyms/Alias
  
Gene Name
 Clu 
Gene Synonyms/Alias
 rCG_52166 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
53QNAVQGVKHIKTLIEacetylation[1]
56VQGVKHIKTLIEKTNacetylation[1]
77LNSLEEAKKKKEGALacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MKILLLCVAL LLTWDNGMVL GEQEFSDNEL QELSTQGSRY VNKEIQNAVQ GVKHIKTLIE 60
KTNAERKSLL NSLEEAKKKK EGALDDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 120
MKFYARVCRS GSGLVGRQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFT 180
RASGIIDTLF QDRFFTHEPQ DIHHFSPMGF PHKRPHFLYP KSRLVRSLMP LSHYGPLSFH 240
NMFQPFFDMI HQAQQAMDVQ LHSPALQFPD VDFLKEGEDD RTVCKEIRHN STGCLKMKGQ 300
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTQQY NELLHSLQSK MLNTSSLLEQ 360
LNDQFSWVSQ LANLTQGDDQ YLRVSTVTTH SSDSEVPSRV TEVVVKLFDS DPITVVLPEE 420
VSKDNPKFMD TVAEKALQEY RRKSRME 447 
Gene Ontology
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0061077; P:chaperone-mediated protein folding; IEA:Compara.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032463; P:negative regulation of protein homooligomerization; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0051788; P:response to misfolded protein; IEA:Compara.
 GO:0009615; P:response to virus; IEA:Compara. 
Interpro
 IPR016016; Clusterin.
 IPR000753; Clusterin-like.
 IPR016015; Clusterin_C.
 IPR016014; Clusterin_N. 
Pfam
 PF01093; Clusterin 
SMART
 SM00035; CLa
 SM00030; CLb 
PROSITE
 PS00492; CLUSTERIN_1
 PS00493; CLUSTERIN_2 
PRINTS