CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008250
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein ZDS1 
Protein Synonyms/Alias
 Protein NRC1; RT2GS1 
Gene Name
 ZDS1 
Gene Synonyms/Alias
 CES1; CKM1; HST1; NRC1; OSS1; STM2; YMR273C; YM8156.15C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
456EQEMGIEKEAEEVPVubiquitination[1]
464EAEEVPVKVRNDTVEubiquitination[1]
559EKTEVSNKEEMNNSSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Has a role in establishing cell polarity. Together with cAMP-dependent protein kinase regulatory subunit BCY1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways. 
Sequence Annotation
 MOD_RES 229 229 Phosphoserine.  
Keyword
 Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; mRNA transport; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 915 AA 
Protein Sequence
MSNRDNESML RTTSSDKAIA SQRDKRKSEV LIAAQSLDNE IRSVKNLKRL SIGSMDLLID 60
PELDIKFGGE SSGRRSWSGT TSSSASMPSD TTTVNNTRYS DPTPLENLHG RGNSGIESSN 120
KTKQGNYLGI KKGVHSPSRK LNANVLKKNL LWVPANQHPN VKPDNFLELV QDTLQNIQLS 180
DNGEDNDGNS NENNDIEDNG EDKESQSYEN KENNTINLNR GLSRHGNASL IRRPSTLRRS 240
YTEFDDNEDD DNKGDSASET VNKVEERISK IKERPVSLRD ITEELTKISN SAGLTDNDAI 300
TLARTLSMAG SYSDKKDQPQ PEGHYDEGDI GFSTSQANTL DDGEFASNMP INNTMTWPER 360
SSLRRSRFNT YRIRSQEQEK EVEQSVDEMK NDDEERLKLT KNTIKVEIDP HKSPFRQQDE 420
DSENMSSPGS IGDFQDIYNH YRQSSGEWEQ EMGIEKEAEE VPVKVRNDTV EQDLELREGT 480
TDMVKPSATD DNKETKRHRR RNGWTWLNNK MSREDDNEEN QGDDENEENV DSQRMELDNS 540
KKHYISLFNG GEKTEVSNKE EMNNSSTSTA TSQTRQKIEK TFANLFRRKP HHKHDASSSP 600
SSSPSSSPSI PNNDAVHVRV RKSKKLGNKS GREPVEPIVL RNRPRPHRHH HSRHGSQKIS 660
VKTLKDSQPQ QQIPLQPQLE GAIEIEKKEE SDSESLPQLQ PAVSVSSTKS NSRDREEEEA 720
KKKNKKRSNT TEISNQQHSK HVQKENTDEQ KAQLQAPAQE QVQTSVPVQA SAPVQNSAPV 780
QTSAPVEASA QTQAPAAPPL KHTSILPPRK LTFADVKKPD KPNSPVQFTD SAFGFPLPLL 840
TVSTVIMFDH RLPINVERAI YRLSHLKLSN SKRGLREQVL LSNFMYAYLN LVNHTLYMEQ 900
VAHDKEQQQQ QQQQP 915 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0005643; C:nuclear pore; IPI:SGD.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IMP:SGD.
 GO:0007569; P:cell aging; IMP:SGD.
 GO:0000078; P:cell shape checkpoint; IGI:SGD.
 GO:0006342; P:chromatin silencing; IMP:SGD.
 GO:0030010; P:establishment of cell polarity; IMP:SGD.
 GO:0006406; P:mRNA export from nucleus; IMP:SGD.
 GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IMP:SGD.
 GO:0032880; P:regulation of protein localization; IMP:SGD. 
Interpro
 IPR013941; ZDS1_C. 
Pfam
 PF08632; Zds_C 
SMART
  
PROSITE
  
PRINTS