CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027089
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-lactate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Ldhal6b 
Gene Synonyms/Alias
 Ldhl; rCG_63067 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
57TMATVKGKLLQHVSSacetylation[1]
109DSNEGKMKGETMDLQacetylation[1]
176IMFANIVKYSPRCKIacetylation[1]
272NSAIGTNKDPEQWGNacetylation[1]
290EVIASAYKIIKMKGYacetylation[1]
357ISDIIKVKLSPTEEAacetylation[1]
368TEEAQMVKSADTIWKacetylation[1]
375KSADTIWKIQKDIKFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Glycolysis; NAD; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MAWAVSILRA RRRMGTVRVD FKDLGVALWP SQVLRVPPNR AWWSLTPTST MATVKGKLLQ 60
HVSSEEPVLH NKVSIIGTGS VGMACAISII AKGLTDELAL VDSNEGKMKG ETMDLQHGSV 120
FMKMPNIVCS KDFHVTANSE VVVITAGARQ EKDETRLNLV QRNVSIFKIM FANIVKYSPR 180
CKIIIVSNPV DILTYVAWKL SGFPKNRVIG SGCNLDTARF RYMLGQRLGI HSESCHGWVL 240
GEHGDSSVPV WSGVNIAGVP LKELNSAIGT NKDPEQWGNV HKEVIASAYK IIKMKGYTSW 300
AIGLSVADIA ESILKNLRKT HPVSTKIKGL YGIKEEVFLS VPCVLGENGI SDIIKVKLSP 360
TEEAQMVKSA DTIWKIQKDI KF 382 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
 PS00064; L_LDH 
PRINTS
 PR00086; LLDHDRGNASE.