CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024699
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cortactin-binding protein 2 
Protein Synonyms/Alias
 CortBP2 
Gene Name
 Cttnbp2 
Gene Synonyms/Alias
 Kiaa1758 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
38FDVDTLSKSELRMLLubiquitination[1]
1544DSRDDLRKFDSSRTNacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. 
Sequence Annotation
 REPEAT 699 729 ANK 1.
 REPEAT 733 762 ANK 2.
 REPEAT 766 795 ANK 3.
 REPEAT 799 828 ANK 4.
 REPEAT 832 861 ANK 5.
 REPEAT 901 931 ANK 6.
 MOD_RES 1510 1510 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; ANK repeat; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1648 AA 
Protein Sequence
MATDSASCEP DLSRTPGDTE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE 60
ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGPGDKEK PVCTNPLSIL EAVMAHCRKM 120
QERMSAQLVA AESRQKKLEM EKLQLQALEQ EHKKLAAHLE EERGKNKHVV LMLVKECKQL 180
SGKVVEEAQK LEEVMAQLEE EKKKTSELEE QLSAEKQRSS GMEAQLEKQL SEFDTEREQL 240
RAKLSREEAH TTDLKEEIDK MKKMMEQMKK GSDGKPGLSL PRKTKDKRLA SISVATEGPV 300
TRSVACQTDV VTESTDPVKK LPLTVPIKPS TGSPLVPTNT KGNVGPSALL IRPGIDRQSS 360
HSDLGPSPPT ALPSSANRIE ENGPSTGNAP DLSNSTPSTP SSTAPAAAQT PGTAPQNHSQ 420
APTVHSLHSP CANTHPGLNP RIQAARFRFQ GNANDPDQNG NNTQSPPSRD VSPTSRDNLV 480
AKQLARNTVT QALSRFTSPQ AGASSRLGVS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP 540
PIPPKKPGLS QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 600
LPPKPSIDLT VAPAGCPVSA LATSQVGAWP AGTPGLNQPA CSDSSLVIPA TVAFCSSINP 660
VSASSRSPGA SDSLLVAASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL 720
NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLNAEARV DAADKNGFTP LCVAAAQGHF 780
ECIELLTAYN ANINHSAAGG QTPLYLACKN GNKECIKLLL EAGTDRSIKT RDGWTPIHAA 840
VDTGNVDSLK LLMYHRVRAH GNSLSSEEPK SGLFSLNGGE SPTGPSKPVV PADLINHADK 900
EGWTAAHIAA SKGFKNCLEV LCRHGGLEPE RRDKCNRTVH DVATDDCKHL LENLNALKIP 960
LRISVGEIQP SNDVSDDFEC EHTICTLNIR KQTSWEDFSK AVSQALTNHF QAISSDGWWS 1020
LEDGTFNNAT DSCIGLGTSS IRSIMLGSMP WSTGQSFSQS PWDFLKKKKV EQVLALLSGP 1080
QEGCLSSVTY ASMIPLQMLQ NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKYRQMAA 1140
GFPCEIVRAE VDSGFSKEQL VDVFIRNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 1200
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLVGTIAK ACLQGSDLLV QQHFRWVQLR 1260
WDCEPIQGLL QRFLRRKVVS KFRGQLPAPC DPVCKIVDWA LSVWRQLNSC LARLGTPEAL 1320
LGPKYFLSCP VVPGHAQATV KWMSKLWNAV IAPRVQEAIL SRASMNKQPG TGQTASKKYP 1380
SQGQQAVVRA ALSILLNKAV LHGCPLPRAE LDQQIADFKG GSFPLSIVSS YSKKKVESGA 1440
WRKVNTSPRK KPGHFSSPTW NKPDPKREGM RNKTIPHLNT NRNSSLSKQQ SLENDLSVTL 1500
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRD DLRKFDSSRT NPGTSAPLNL 1560
RTPVPQKEAS PPSSRQTAEC SNSKSKTEMG VSSVKSFLPV PRSKVAQCSQ NTKRNSSSSN 1620
TRQLEINNNS KEENWTLDKH EQVEKPNK 1648 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR019131; Cortactin-binding_p2_N. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF09727; CortBP2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS