UniProt Accession

 GHRL_RAT; Q9QYH7; Q9ET69 

Genbank Protein ID

 AB029433; AB035699 

Genbank Nucleotide ID

 BAA89370.1; BAB11956.1 

Protein Name

 Appetite-regulating hormone 

Protein Synonyms/Alias

 Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Ghrelin; Obestatin-23; Obestatin-13 

Gene Name

 Ghrl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
47	ESKKPPAKLQPRALE	acetylation	[1]
100	QHGRALGKFLQDILW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. 

Sequence Annotation

 MOD_RES 98 98 Leucine amide.
 LIPID 26 26 O-octanoyl serine.  

Keyword

 Alternative splicing; Amidation; Complete proteome; Direct protein sequencing; Hormone; Lipoprotein; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0031768; F:ghrelin receptor binding; IMP:RGD.
 GO:0016608; F:growth hormone-releasing hormone activity; IDA:UniProtKB.
 GO:0030296; F:protein tyrosine kinase activator activity; ISS:UniProtKB.
 GO:0008154; P:actin polymerization or depolymerization; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
 GO:0008343; P:adult feeding behavior; ISS:HGNC.
 GO:0046697; P:decidualization; ISS:UniProtKB.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:UniProtKB.
 GO:0001696; P:gastric acid secretion; IDA:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0042322; P:negative regulation of circadian sleep/wake cycle, REM sleep; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:UniProtKB.
 GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
 GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
 GO:0032691; P:negative regulation of interleukin-1 beta production; ISS:UniProtKB.
 GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; ISS:UniProtKB.
 GO:0040013; P:negative regulation of locomotion; IEA:Compara.
 GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; ISS:UniProtKB.
 GO:0032100; P:positive regulation of appetite; ISS:HGNC.
 GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; IEA:Compara.
 GO:0051461; P:positive regulation of corticotropin secretion; IEA:Compara.
 GO:0051464; P:positive regulation of cortisol secretion; IEA:Compara.
 GO:0060124; P:positive regulation of growth hormone secretion; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IDA:UniProtKB.
 GO:0051965; P:positive regulation of synapse assembly; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; ISS:UniProtKB. 

Interpro

 IPR006737; Motilin_assoc.
 IPR006738; Motilin_ghrelin.
 IPR005441; Preproghrelin. 

Pfam

 PF04643; Motilin_assoc
 PF04644; Motilin_ghrelin 

SMART

  

PROSITE

  

PRINTS

 PR01624; GHRELIN.