UniProt Accession

 RPAP3_HUMAN; Q9H6T3; B4DRW9; Q6PHR5 

Genbank Protein ID

 AK025561; AK299465; AC004241; CH471111; BC056415 

Genbank Nucleotide ID

 BAB15170.1; BAG61431.1; EAW57938.1; AAH56415.1 

Protein Name

 RNA polymerase II-associated protein 3 

Protein Synonyms/Alias

  

Gene Name

 RPAP3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	RDLENWEKDIKQKDM	ubiquitination	[1]
86	ENTKNRIKSYDYEAW	ubiquitination	[1]
216	AARFALQKLEEAKKD	acetylation	[2]
607	DFYIEKEKPLLIFEI	acetylation	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. 

Sequence Annotation

 REPEAT 8 41 TPR 1.
 REPEAT 133 166 TPR 2.
 REPEAT 168 200 TPR 3.
 REPEAT 201 234 TPR 4.
 REPEAT 282 315 TPR 5.
 REPEAT 317 349 TPR 6.
 REPEAT 350 383 TPR 7.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 481 481 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 665 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR025986; RPAP3-like_C.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF13877; RPAP3_C
 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS