CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028358
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450, family 7, subfamily a, polypeptide 1 
Protein Synonyms/Alias
  
Gene Name
 Cyp7a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28IIGIRRRKVGEPPLDubiquitination[1]
127NTTENINKTFNKTLQubiquitination[1]
229GVPIHLFKTAHKAREubiquitination[1]
275STFDDMEKAKTHLVIubiquitination[1]
367SLNIRTAKEDFTLHLubiquitination[1]
418RYLDESGKAKTTFYRubiquitination[1]
420LDESGKAKTTFYRNGubiquitination[1]
498PLNDIEFKYKLKH**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 METAL 444 444 Iron (heme axial ligand) (By similarity).  
Keyword
 Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MMSISLIWGI AVVVSCCIWF IIGIRRRKVG EPPLDNGLIP YLGCALKFGS NPLEFLRAKQ 60
RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPSDGN 120
TTENINKTFN KTLQGDALCS LSEAMMQNLQ SVMRPPGLPK SKSAVWVTEG MYAFCYRVMF 180
EAGYLTLFGK DISKTDTQRA FIQNNLDSFK QFDQVFPALV AGVPIHLFKT AHKARERLAE 240
SLKHKNLYMR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL VILWASQANT IPATFWSLFQ 300
MIRSPEAMKA ASEEVNGSLQ SAGQELSSGG NAIYLDQEQL NNLPVLDSII KEALRLSSAS 360
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDESGKAK 420
TTFYRNGNKL KYFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSYFELELV ESHTKCPPLD 480
QSRAGLGILP PLNDIEFKYK LKH 503 
Gene Ontology
 GO:0008123; F:cholesterol 7-alpha-monooxygenase activity; IDA:MGI.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0006707; P:cholesterol catabolic process; IDA:MGI. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR024204; Cyt_P450_CYP7A1-type.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.