UniProt Accession

 NADC_MOUSE; Q91X91 

Genbank Protein ID

 BC011191 

Genbank Nucleotide ID

 AAH11191.1 

Protein Name

 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 

Protein Synonyms/Alias

 Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase 

Gene Name

 Qprt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
86	SKLVPVVKVAEVKGP	ubiquitination	[1]
149	PGFRLVEKYGLQVGG	ubiquitination	[1]
171	LGGMVMVKDNHVVAA	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Involved in the catabolism of quinolinic acid (QA) (By similarity). 

Sequence Annotation

 REGION 137 139 Substrate binding (By similarity).
 REGION 248 250 Substrate binding (By similarity).
 REGION 269 271 Substrate binding (By similarity).
 BINDING 102 102 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 201 201 Substrate (By similarity).
 BINDING 222 222 Substrate (By similarity).  

Keyword

 Complete proteome; Glycosyltransferase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:EC.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0034213; P:quinolinate catabolic process; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR004393; NadC.
 IPR027277; NadC/ModD.
 IPR002638; Quinolinate_PRibosylTrfase_C.
 IPR022412; Quinolinate_PRibosylTrfase_N. 

Pfam

 PF01729; QRPTase_C
 PF02749; QRPTase_N 

SMART

  

PROSITE

  

PRINTS