CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028082
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Malate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Mdh1 
Gene Synonyms/Alias
 CG5362-RA; CG5362; Dmel_CG5362 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
118TQGQALDKFAKKDVKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MAEPIRVVVT GAAGQIAYSL LYMIARGEVF GKDQPIVLHL LDIPPMVGVL EGVVMELADC 60
ALPLLVEVVP TTDPAVGFKD VSAAFLVGAM PRKEGMERKD LLSANVKIFR TQGQALDKFA 120
KKDVKVLVVG NPANTNALVC SSYAPSIPRE NFSAMTRLDQ NRATSQIAAK LGVPISAVKN 180
IIIWGNHSST QYPDAGQAKV TANGTVKSVV DAINDNGYLQ GSFVETVQKR GAAVIAARKM 240
SSAMSAAKAA CDHMHDWWNG TAPGQFVSMG VFSDGSYDSP KDVIFSFPVE IKNKQWKIVS 300
GLTLSDFAKT KLSVTGKELQ EEKDEALSVL DSNVSNL 337 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0030060; F:L-malate dehydrogenase activity; IDA:FlyBase.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR011274; Malate_DH_NAD-dep_euk.
 IPR010945; Malate_DH_type2.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
 PS00068; MDH 
PRINTS