UniProt Accession

 OLA1_MOUSE; Q9CZ30; B1AYJ8; B1AYK0; Q9CWE2; Q9CX91; Q9CYC9; Q9CZ56 

Genbank Protein ID

 AK010817; AK013055; AK017803; AK019142; BX284615; AL928608; BX284615; AL928608; AL928608; BX284615; AL928608; BX284615; BC011318; BC029207 

Genbank Nucleotide ID

 BAB27201.1; BAB28624.1; BAB31566.1; CAM17550.1; CAM17550.1; CAM17551.1; CAM17551.1; CAM19352.1; CAM19352.1; CAM19354.1; CAM19354.1; AAH11318.1; AAH29207.1 

Protein Name

 Obg-like ATPase 1 

Protein Synonyms/Alias

 GTP-binding protein 9 

Gene Name

 Ola1 

Gene Synonyms/Alias

 Gtpbp9 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
281	LSAEERQKYLEANMT	ubiquitination	[1]
294	MTQSALPKIIKAGFA	acetylation	[2, 3, 4]
340	KIHTDFEKGFIMAEV	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity). 

Sequence Annotation

 DOMAIN 24 131 G.
 NP_BIND 32 37 ATP (By similarity).
 MOTIF 267 274 Nuclear export signal (Potential).
 BINDING 231 231 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 294 294 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0006200; P:ATP catabolic process; IEA:Compara. 

Interpro

 IPR012675; Beta-grasp_dom.
 IPR004396; CHP00092.
 IPR013029; DUF933.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase.
 IPR012676; TGS-like.
 IPR023192; TGS-like_dom. 

Pfam

 PF01926; MMR_HSR1
 PF06071; YchF-GTPase_C 

SMART

  

PROSITE

  

PRINTS

 PR00326; GTP1OBG.