CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013770
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 4 regulatory subunit 3B 
Protein Synonyms/Alias
 SMEK homolog 2 
Gene Name
 SMEK2 
Gene Synonyms/Alias
 KIAA1387; PP4R3B; PPP4R3B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
249LTKTAKFKEVIPITDubiquitination[1, 2]
459ATTNKTEKSEFLNFFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. 
Sequence Annotation
 DOMAIN 1 100 WH1.
 MOD_RES 117 117 Phosphoserine.
 MOD_RES 840 840 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 849 AA 
Protein Sequence
MSDTRRRVKV YTLNEDRQWD DRGTGHVSST YVEELKGMSL LVRAESDGSL LLESKINPNT 60
AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVEVT QDLIDESEEE 120
RFEEMPETSH LIDLPTCELN KLEEIADLVT SVLSSPIRRE KLALALENEG YIKKLLQLFQ 180
ACENLENTEG LHHLYEIIRG ILFLNKATLF EVMFSDECIM DVVGCLEYDP ALAQPKRHRE 240
FLTKTAKFKE VIPITDSELR QKIHQTYRVQ YIQDIILPTP SVFEENFLST LTSFIFFNKV 300
EIVSMLQEDE KFLSEVFAQL TDEATDDDKR RELVNFFKEF CAFSQTLQPQ NRDAFFKTLA 360
KLGILPALEI VMGMDDLQVR SAATDIFSYL VEFSPSMVRE FVMQEAQQSD DDILLINVVI 420
EQMICDTDPE LGGAVQLMGL LRTLIDPENM LATTNKTEKS EFLNFFYNHC MHVLTAPLLT 480
NTSEDKCEKD FFLKHYRYSW SFICTPSHSH SHSTPSSSIS QDNIVGSNKN NTICPDNYQT 540
AQLLALILEL LTFCVEHHTY HIKNYIMNKD LLRRVLVLMN SKHTFLALCA LRFMRRIIGL 600
KDEFYNRYIT KGNLFEPVIN ALLDNGTRYN LLNSAVIELF EFIRVEDIKS LTAHIVENFY 660
KALESIEYVQ TFKGLKTKYE QEKDRQNQKL NSVPSILRSN RFRRDAKALE EDEEMWFNED 720
EEEEGKAVVA PVEKPKPEDD FPDNYEKFME TKKAKESEDK ENLPKRTSPG GFKFTFSHSA 780
SAANGTNSKS VVAQIPPATS NGSSSKTTNL PTSVTATKGS LVGLVDYPDD EEEDEEEESS 840
PRKRPRLGS 849 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0030289; C:protein phosphatase 4 complex; IEA:Compara.
 GO:0045722; P:positive regulation of gluconeogenesis; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:Compara. 
Interpro
 IPR016024; ARM-type_fold.
 IPR006887; DUF625.
 IPR011993; PH_like_dom. 
Pfam
 PF04802; SMK-1 
SMART
  
PROSITE
 PS50229; WH1 
PRINTS