UniProt Accession

 DENR_HUMAN; O43583; Q9H3U6; Q9UKZ0 

Genbank Protein ID

 AF038554; AB014731; AC026331; AC027290; BC007860; AF103800 

Genbank Nucleotide ID

 AAC02985.2; BAB20268.1; AAH07860.1; AAF02420.1 

Protein Name

 Density-regulated protein 

Protein Synonyms/Alias

 DRP; Protein DRP1; Smooth muscle cell-associated protein 3; SMAP-3 

Gene Name

 DENR 

Gene Synonyms/Alias

 DRP1; H14 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	ESSGADCKGDPRNSA	ubiquitination	[1]
59	KCRQWLEKNFPNEFA	ubiquitination	[2]
75	LTVENSPKQEAGISE	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays a role in the modulation of the translational profile of a subset of cancer- related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. 

Sequence Annotation

 DOMAIN 115 182 SUI1.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 73 73 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0003743; F:translation initiation factor activity; IEA:InterPro. 

Interpro

 IPR005873; Drp1.
 IPR001950; TIF_SUI1. 

Pfam

 PF01253; SUI1 

SMART

  

PROSITE

 PS50296; SUI1 

PRINTS