UniProt Accession

 SERA_RAT; O08651; Q546Q9 

Genbank Protein ID

 X97772; AJ271975; BC086327 

Genbank Nucleotide ID

 CAA66374.1; CAB89828.1; AAH86327.1 

Protein Name

 D-3-phosphoglycerate dehydrogenase 

Protein Synonyms/Alias

 3-PGDH 

Gene Name

 Phgdh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
58	LIVRSATKVTADVIN	acetylation	[1]
58	LIVRSATKVTADVIN	ubiquitination	[2]
132	TASMKDGKWDRKKFM	acetylation	[1]
137	DGKWDRKKFMGTELN	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

  

Sequence Annotation

 NP_BIND 155 156 NAD (By similarity).
 NP_BIND 234 236 NAD (By similarity).
 NP_BIND 283 286 NAD (By similarity).
 ACT_SITE 236 236 By similarity.
 ACT_SITE 265 265 By similarity.
 ACT_SITE 283 283 Proton donor (By similarity).
 BINDING 78 78 NAD (By similarity).
 BINDING 175 175 NAD (By similarity).
 BINDING 207 207 NAD; via carbonyl oxygen (By similarity).
 BINDING 260 260 NAD (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 533 AA 

Protein Sequence

Gene Ontology

 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; IDA:RGD.
 GO:0022402; P:cell cycle process; IEA:Compara.
 GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:Compara.
 GO:0021782; P:glial cell development; IEA:Compara.
 GO:0006541; P:glutamine metabolic process; IEA:Compara.
 GO:0006544; P:glycine metabolic process; IEA:Compara.
 GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
 GO:0021915; P:neural tube development; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0009070; P:serine family amino acid biosynthetic process; TAS:RGD.
 GO:0021510; P:spinal cord development; IEA:Compara.
 GO:0019530; P:taurine metabolic process; IEA:Compara.
 GO:0006566; P:threonine metabolic process; IEA:Compara. 

Interpro

 IPR006236; D-3-Phosphoglycerate_DH.
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS