UniProt Accession

 UPP_SALTY; P0A2M5; Q93A76 

Genbank Protein ID

 AF427145; AE006468 

Genbank Nucleotide ID

 AAL28076.1; AAL21392.1 

Protein Name

 Uracil phosphoribosyltransferase 

Protein Synonyms/Alias

 UMP pyrophosphorylase; UPRTase 

Gene Name

 upp 

Gene Synonyms/Alias

 STM2498 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
14	KHPLVKHKLGLMREN	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity). 

Sequence Annotation

 REGION 130 138 5-phospho-alpha-D-ribose 1-diphosphate
 REGION 198 200 Uracil binding (By similarity).
 BINDING 78 78 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 103 103 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 193 193 Uracil; via amide nitrogen (By
 BINDING 199 199 5-phospho-alpha-D-ribose 1-diphosphate  

Keyword

 Allosteric enzyme; Complete proteome; Glycosyltransferase; GTP-binding; Magnesium; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004845; F:uracil phosphoribosyltransferase activity; IEA:HAMAP.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
 GO:0006223; P:uracil salvage; IEA:InterPro. 

Interpro

 IPR000836; PRibTrfase_dom.
 IPR005765; Ura_phspho_trans. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

  

PRINTS