CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kin of IRRE-like protein 1 
Protein Synonyms/Alias
 cDNA FLJ56360, highly similar to Kin of IRRE-like protein 1 
Gene Name
 KIRREL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
469STATRVMKAIYSSFKubiquitination[1]
482FKDDVDLKQDLRCDTubiquitination[1, 2, 3]
499TREEYEMKDPTNGYYubiquitination[1, 2, 3]
629EAYDPIGKYATATRFubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MLSLLVWILT LSDTFSQVPP EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG 60
TQQEGAVAST ELLKDGKRET TVSQLLINPT DLDIGRVFTC RSMNEAIPSG KETSIELDVH 120
HPPTVTLSIE PQTVQEGERV VFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF 180
FTEPVSCEVH NKVGSTNVST LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT 240
WTKKDSNMVL SNSNQLLLKS VTQADAGTYT CRAIVPRIGV AEREVPLYVN GPPIISSEAV 300
QYAVRGDGGK VECFIGSTPP PDRIAWAWKE NFLEVGTLER YTVERTNSGS GVLSTLTINN 360
VMEADFQTHY NCTAWNSFGP GTAIIQLEER EVLPVGIIAG ATIGASILLI FFFIALVFFL 420
YRRRKGSRKD VTLRKLDIKV ETVNREPLTM HSDREDDTAS VSTATRVMKA IYSSFKDDVD 480
LKQDLRCDTI DTREEYEMKD PTNGYYNVRA HEDRPSSRAV LYADYRAPGP ARFDGRPSSR 540
LSHSSGYAQL NTYSRGPASD YGPEPTPPGP AAPAGTDTTS QLSYENYEKF NSHPFPGAAG 600
YPTYRLGYPQ APPSGLERTP YEAYDPIGKY ATATRFSYTS QHSDYGQRFQ QRMQTHV 657 
Gene Ontology
 GO:0016020; C:membrane; IEA:UniProtKB-KW. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF08205; C2-set_2 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS