UniProt Accession

 VA0D_YEAST; P32366; D6VZ81 

Genbank Protein ID

 L11584; U22382; BK006945 

Genbank Nucleotide ID

 AAA35210.1; AAB67533.1; DAA09747.1 

Protein Name

 V-type proton ATPase subunit d 

Protein Synonyms/Alias

 V-ATPase subunit d; V-ATPase 39 kDa subunit; V-ATPase subunit M39; Vacuolar proton pump subunit d 

Gene Name

 VMA6 

Gene Synonyms/Alias

 YLR447C; L9324.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
120	GTIHDRDKGEILQRC	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Reference proteome; Transport; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; TAS:SGD.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IMP:SGD.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0007035; P:vacuolar acidification; TAS:SGD.
 GO:0007034; P:vacuolar transport; IMP:SGD. 

Interpro

 IPR002843; ATPase_V0-cplx_csu/dsu.
 IPR016727; ATPase_V0-cplx_dsu. 

Pfam

 PF01992; vATP-synt_AC39 

SMART

  

PROSITE

  

PRINTS