UniProt Accession

 IRF5_HUMAN; Q13568; A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0 

Genbank Protein ID

 AY504947; AY504946; AY693665; AY693666; AY693668; DQ277633; U51127; EF064718; AC025594; CH236950; CH236950; CH471070; CH471070; BC004201; BC004139; DQ995495; DQ995496 

Genbank Nucleotide ID

 AAR90326.1; AAR90325.1; AAU12877.1; AAU12878.1; AAU12880.1; ABB88960.1; AAA96056.1; ABK41901.1; EAL24107.1; EAL24108.1; EAW83703.1; EAW83705.1; AAH04201.1; AAH04139.1; ABL96293.1; ABL96294.1 

Protein Name

 Interferon regulatory factor 5 

Protein Synonyms/Alias

 IRF-5 

Gene Name

 IRF5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
411	PDRKPREKKLITVQV	ubiquitination	[1]
412	DRKPREKKLITVQVV	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. 

Sequence Annotation

 DNA_BIND 14 122 IRF tryptophan pentad repeat.
 MOTIF 12 18 Nuclear localization signal.
 MOTIF 150 160 Nuclear export signal.
 MOD_RES 10 10 Phosphothreonine.
 MOD_RES 158 158 Phosphoserine; by TBK1.
 MOD_RES 293 293 Phosphoserine; by TBK1.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 435 435 Phosphoserine.
 MOD_RES 437 437 Phosphoserine.
 MOD_RES 440 440 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.
 CROSSLNK 411 411 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 412 412 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; DNA-binding; Immunity; Innate immunity; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 498 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL.
 GO:0032727; P:positive regulation of interferon-alpha production; IC:BHF-UCL.
 GO:0032728; P:positive regulation of interferon-beta production; IC:BHF-UCL.
 GO:0032735; P:positive regulation of interleukin-12 production; IC:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0032495; P:response to muramyl dipeptide; IDA:BHF-UCL.
 GO:0032494; P:response to peptidoglycan; IDA:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR019817; Interferon_reg_fac_CS.
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00605; IRF
 PF10401; IRF-3 

SMART

 SM00348; IRF 

PROSITE

 PS00601; IRF_1
 PS51507; IRF_2 

PRINTS

 PR00267; INTFRNREGFCT.