CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal transducer and activator of transcription 6 
Protein Synonyms/Alias
  
Gene Name
 STAT6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9SLWGLVSKMPPEKVQubiquitination[1, 2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 105 AA 
Protein Sequence
MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC NLASALLSDT 60
VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR QILQG 105 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0060443; P:mammary gland morphogenesis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0002829; P:negative regulation of type 2 immune response; IEA:Compara.
 GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0002296; P:T-helper 1 cell lineage commitment; IEA:Compara. 
Interpro
 IPR001217; STAT_TF_core.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF02865; STAT_int 
SMART
  
PROSITE
  
PRINTS