CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010065
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Acetate kinase 
Protein Synonyms/Alias
 Acetokinase 
Gene Name
 ackA 
Gene Synonyms/Alias
 MPN_533; MP309 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
50KLEFNEQKVEEKVAFacetylation[1]
123KLAPLHNKPEADVIEacetylation[1]
169VPRSWEQKHLVRRYGacetylation[1]
191FINNYLEKHLNKQNLacetylation[1]
266DVVNALNKKSGMLALacetylation[1]
285DMRDVFAKPQENAVAacetylation[1]
353TDLKLFVKYGDSCVVacetylation[1]
366VVSTPQSKYKIYRVRacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity). 
Sequence Annotation
 NP_BIND 204 208 ATP (By similarity).
 NP_BIND 278 280 ATP (By similarity).
 NP_BIND 323 327 ATP (By similarity).
 ACT_SITE 146 146 Proton donor/acceptor (By similarity).
 METAL 10 10 Magnesium (By similarity).
 METAL 376 376 Magnesium (By similarity).
 BINDING 17 17 ATP (By similarity).
 BINDING 89 89 Substrate (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MNDNKILVVN AGSSSIKFQL FDYHKKVLAK ALCERIFVDG FFKLEFNEQK VEEKVAFPDH 60
HAAVTHFLNT LKKHKIIQEL SDIILVGHRV VQGANYFKDS VIVDAEALAK IKEFIKLAPL 120
HNKPEADVIE IFFKEVPSAK NVAVFDTTFH TTIPQENYLY AVPRSWEQKH LVRRYGFHGT 180
SYKFINNYLE KHLNKQNLNL IVCHLGNGAS VCAIKNGKSF NTSMGFTPLE GLIMGTRSGD 240
LDPAIIGYVA EQENMSASDV VNALNKKSGM LALTGASDMR DVFAKPQENA VAIKMYVNRV 300
ADYIAKYLNQ LEGNIDGLVF TGGIGENASD CVELFINAVK SLGFATDLKL FVKYGDSCVV 360
STPQSKYKIY RVRTNEELMI VEDSIRLTQK 390 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008776; F:acetate kinase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006082; P:organic acid metabolic process; IEA:InterPro. 
Interpro
 IPR004372; Ac/Proprionate_kinase.
 IPR000890; Aliphatic_acid_kin_short-chain.
 IPR023865; Aliphatic_acid_kinase_CS. 
Pfam
 PF00871; Acetate_kinase 
SMART
  
PROSITE
 PS01075; ACETATE_KINASE_1
 PS01076; ACETATE_KINASE_2 
PRINTS
 PR00471; ACETATEKNASE.