UniProt Accession

 SDC1_HUMAN; P18827; D6W523; Q53QV0; Q546D3; Q96HB7 

Genbank Protein ID

 X60306; J05392; AJ551176; AC104792; CH471053; CH471053; CH471053; CH471053; BC008765; Z48199 

Genbank Nucleotide ID

 CAA42851.1; AAA60605.1; CAD80245.1; AAX93151.1; EAX00828.1; EAX00829.1; EAX00830.1; EAX00831.1; AAH08765.1; CAA88235.1 

Protein Name

 Syndecan-1 

Protein Synonyms/Alias

 SYND1; CD138 

Gene Name

 SDC1 

Gene Synonyms/Alias

 SDC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
292	SYSLEEPKQANGGAY	ubiquitination	[1]
301	ANGGAYQKPTKQEEF	ubiquitination	[1, 2, 3]
304	GAYQKPTKQEEFYA*	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. 

Sequence Annotation

 CARBOHYD 37 37 O-linked (Xyl...) (chondroitin sulfate)
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 45 45 O-linked (Xyl...) (heparan sulfate) (By
 CARBOHYD 47 47 O-linked (Xyl...) (heparan sulfate) (By
 CARBOHYD 206 206 O-linked (Xyl...) (chondroitin sulfate)
 CARBOHYD 216 216 O-linked (Xyl...) (chondroitin sulfate)  

Keyword

 3D-structure; Complete proteome; Glycoprotein; Heparan sulfate; Membrane; Polymorphism; Proteoglycan; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030204; P:chondroitin sulfate metabolic process; TAS:Reactome.
 GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
 GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0048627; P:myoblast development; ISS:UniProtKB.
 GO:0042476; P:odontogenesis; IEA:Compara.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0060009; P:Sertoli cell development; IEA:Compara.
 GO:0055002; P:striated muscle cell development; IEP:UniProtKB.
 GO:0001657; P:ureteric bud development; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR003585; Neurexin-like.
 IPR001050; Syndecan. 

Pfam

 PF01034; Syndecan 

SMART

 SM00294; 4.1m 

PROSITE

 PS00964; SYNDECAN 

PRINTS