| Tag | Content |
|---|
| CPLM ID | CPLM-013060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Extended synaptotagmin-1 |
Protein Synonyms/Alias | E-Syt1; Membrane-bound C2 domain-containing protein |
Gene Name | Esyt1 |
Gene Synonyms/Alias | Fam62a; Mbc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 339 | SSKDKYVKGLIEGKS | ubiquitination | [1] | | 345 | VKGLIEGKSDPYALV | ubiquitination | [1] | | 536 | QELDVQVKDDSRALT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role as calcium-regulated intrinsic membrane protein (By similarity). |
Sequence Annotation | DOMAIN 306 407 C2 1.
DOMAIN 455 548 C2 2.
DOMAIN 621 722 C2 3.
DOMAIN 772 864 C2 4.
DOMAIN 950 1065 C2 5.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 804 804 N6-acetyllysine (By similarity).
MOD_RES 807 807 Phosphoserine (By similarity).
MOD_RES 951 951 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1092 AA |
Protein Sequence | MEHSPEEGAS PEPSGQPPAT DSTRDGGSGV PPAGPGAASE ALAVLTSFGR RLLVLVPVYL 60
AGAAGLSVGF VLFGLALYLG WRRVRDGKER SLRAARQLLD DEERITAETL YMSHRELPAW 120
VSFPDVEKAE WLNKIVAQVW PFLGQYMEKL LAETVAPAVR GANPHLQTFT FTRVELGEKP 180
LRIIGVKVHP SQRKDQILLD LNVSYVGDVQ IDVEVKKYFC KAGVKGMQLH GVLRVILEPL 240
TGDLPIVGAV SMFFIKRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA FLVLPNRLLV 300
PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG LIEGKSDPYA LVRVGTQTFC 360
SRVIDEELNP HWGETYEVIV HEVPGQEIEV EVFDKDPDKD DFLGRMKLDV GKVLQAGVLD 420
NWYPLQGGQG QVHLRLEWLS LLPDAEKLDQ VLQWNRGITS RPEPPSAAIL VVYLDRAQDL 480
PLKKGNKEPN PMVQLSVQDV TRESKATYST NSPVWEEAFR FFLQDPRSQE LDVQVKDDSR 540
ALTLGALTLP LARLLTASEL TLDQWFQLSS SGPNSRLYMK LVMRILYLDY SEIRFPTVPG 600
AQDWDRESLE TGSSVDAPPR PYHTTPNSHF GTENVLRIHV LEAQDLIAKD RFLGGLVKGK 660
SDPYVKLKVA GKSFRTHVVR EDLNPRWNEV FEVIVTSIPG QELEIEVFDK DLDKDDFLGR 720
YKVSLTTVLN SGFLDEWLTL EDVPSGRLHL RLERLTPRPT AAELEEVLQV NSLIQTQKSS 780
ELAAALLSVF LERAEDLPLR KGTKPPSPYA TITVGETSHK TKTVSQSSAP VWEESASFLI 840
RKPHAESLEL QVRGEGTGTL GSVSLPLSEL LQEDQLCLDH WFALSGQGQV LMRAQLGILV 900
SQHSGVEAHS HSYSHSHSSS SLNDEPEALG GPTHPASPVL EVRHRLTHGD SPSEAPVGPL 960
GQVKLTVWYH SDEQKLISII HSCRALRQNG RDLPDPYVSV LLLPDKNRST KRKTPQKKRT 1020
LNPEFNERFE WDLPLDGTLR RKLDVSVKSN SSFMSREREL LGKVQLDLAE IDLSQGAAQW 1080
YDLMDDRDKG GS 1092 |
Gene Ontology | GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |