CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoinositide 3-kinase regulatory subunit 5 
Protein Synonyms/Alias
 PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K 
Gene Name
 PIK3R5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256ARRWLRTKLQAVGEKubiquitination[1]
429IRIYKLFKSTSQLVLubiquitination[2, 3]
562QFFYVPVKRSHGTSPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). 
Sequence Annotation
 REGION 25 101 Heterodimerization (By similarity).
 REGION 653 753 Interaction with beta-gamma G protein
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 458 458 Phosphoserine.
 MOD_RES 507 507 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 880 AA 
Protein Sequence
MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR DPGHFLILLE 60
QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD LLLKAASTYH RFLTWPVPYC 120
SICQELLTFI DAELKAPGIS YQRLVRAEQG LPIRSHRSST VTVLLLNPVE VQAEFLAVAN 180
KLSTPGHSPH SAYTTLLLHA FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA 240
SGIGDAAEAR RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI 300
LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS SLASHDSTLS 360
LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS EWPWRRGSQE RRGHRRPGQK 420
FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP 480
QPKLGTQLPS WLLAPASRPQ RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR 540
LENNRPLLTR FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW 600
EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT QLPILADMLL 660
YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS AATRAIKASG PGSKRLGIDG 720
DREAVPLTLQ IIYSKGAISG RSRWSNLEKV CTSVNLNKAC RKQEELDSSM EALTLNLTEV 780
VKRQNSKSKK GFNQISTSQI KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK 840
PEKSDLSSPP QTPPDLPAQA APDLCSLLCL PIMTFSGALP 880 
Gene Ontology
 GO:0005944; C:1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex; ISS:UniProtKB.
 GO:0016020; C:membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:Compara.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; ISS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.
 GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR019522; PI3K_1B_gamma_p101_su. 
Pfam
 PF10486; PI3K_1B_p101 
SMART
  
PROSITE
  
PRINTS