UniProt Accession

 GSTM1_HUMAN; P09488; Q5GHG0; Q6FH88; Q8TC98; Q9UC96 

Genbank Protein ID

 X08020; J03817; AY510272; AY532926; AY532927; CR541868; BC024005; X68676; X51451 

Genbank Nucleotide ID

 CAA30821.1; AAA59203.1; AAR85979.1; AAT06767.1; AAT06768.1; CAG46666.1; AAH24005.1; CAA48636.1; CAA35817.1 

Protein Name

 Glutathione S-transferase Mu 1 

Protein Synonyms/Alias

 GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4 

Gene Name

 GSTM1 

Gene Synonyms/Alias

 GST1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	TDSSYEEKKYTMGDA	ubiquitination	[1]
32	DSSYEEKKYTMGDAP	ubiquitination	[1]
50	RSQWLNEKFKLGLDF	ubiquitination	[1]
52	QWLNEKFKLGLDFPN	ubiquitination	[1]
126	EFEKLKPKYLEELPE	acetylation	[2]
144	LYSEFLGKRPWFAGN	ubiquitination	[1]
193	SRFEGLEKISAYMKS	ubiquitination	[1]
199	EKISAYMKSSRFLPR	acetylation	[3]
199	EKISAYMKSSRFLPR	ubiquitination	[1]
211	LPRPVFSKMAVWGNK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 2 88 GST N-terminal.
 DOMAIN 90 208 GST C-terminal.
 REGION 7 8 Glutathione binding.
 REGION 46 50 Glutathione binding.
 REGION 59 60 Glutathione binding.
 REGION 72 73 Glutathione binding.
 BINDING 116 116 Substrate.
 MOD_RES 23 23 Phosphotyrosine (By similarity).
 MOD_RES 33 33 Phosphotyrosine (By similarity).
 MOD_RES 34 34 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043295; F:glutathione binding; IDA:BHF-UCL.
 GO:0004364; F:glutathione transferase activity; IDA:BHF-UCL.
 GO:0070458; P:cellular detoxification of nitrogen compound; IDA:BHF-UCL.
 GO:0006749; P:glutathione metabolic process; IDA:BHF-UCL.
 GO:0018916; P:nitrobenzene metabolic process; IDA:BHF-UCL.
 GO:0042178; P:xenobiotic catabolic process; IDA:BHF-UCL. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.