UniProt Accession

 CY24B_HUMAN; P04839; A8K138; Q2PP16 

Genbank Protein ID

 X04011; AF469769; AF469757; AF469758; AF469759; AF469760; AF469761; AF469762; AF469763; AF469764; AF469765; AF469766; AF469767; AF469768; DQ314869; AK289753; CH471141; BC032720; X05895; AB013904 

Genbank Nucleotide ID

 CAA27635.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; AAL76082.1; ABC40728.1; BAF82442.1; EAW59453.1; AAH32720.1; CAA29327.1; BAA34183.1 

Protein Name

 Cytochrome b-245 heavy chain 

Protein Synonyms/Alias

 CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome 

Gene Name

 CYBB 

Gene Synonyms/Alias

 NOX2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	PKFFYTRKLLGSALA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. 

Sequence Annotation

 DOMAIN 54 286 Ferric oxidoreductase.
 DOMAIN 287 397 FAD-binding FR-type.
 NP_BIND 338 344 FAD (Potential).
 METAL 101 101 Iron (heme axial ligand) (Probable).
 METAL 115 115 Iron (heme axial ligand) (Probable).
 METAL 209 209 Iron (heme axial ligand) (Probable).
 METAL 222 222 Iron (heme axial ligand) (Probable).
 CARBOHYD 132 132 N-linked (GlcNAc...).
 CARBOHYD 149 149 N-linked (GlcNAc...).
 CARBOHYD 240 240 N-linked (GlcNAc...).  

Keyword

 3D-structure; Cell membrane; Chronic granulomatous disease; Complete proteome; Direct protein sequencing; Disease mutation; Electron transport; FAD; Glycoprotein; Heme; Ion channel; Ion transport; Iron; Membrane; Metal-binding; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 570 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043020; C:NADPH oxidase complex; IDA:BHF-UCL.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0050660; F:flavin adenine dinucleotide binding; IMP:BHF-UCL.
 GO:0020037; F:heme binding; IMP:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016175; F:superoxide-generating NADPH oxidase activity; TAS:BHF-UCL.
 GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0050665; P:hydrogen peroxide biosynthetic process; IEA:Compara.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0045087; P:innate immune response; IMP:BHF-UCL.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0045730; P:respiratory burst; IMP:BHF-UCL.
 GO:0042554; P:superoxide anion generation; IDA:BHF-UCL. 

Interpro

 IPR000778; Cyt_b245_heavy_chain.
 IPR013112; FAD-bd_8.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR013130; Fe3_Rdtase_TM_dom.
 IPR013121; Fe_red_NAD-bd_6.
 IPR017938; Riboflavin_synthase-like_b-brl. 

Pfam

 PF08022; FAD_binding_8
 PF01794; Ferric_reduct
 PF08030; NAD_binding_6 

SMART

  

PROSITE

 PS51384; FAD_FR 

PRINTS

 PR00466; GP91PHOX.