| Tag | Content |
|---|
| CPLM ID | CPLM-019978 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Unconventional myosin-VIIb |
Protein Synonyms/Alias | |
Gene Name | Myo7b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 624 | FKSSDSIKRPVTLAS | ubiquitination | [1] | | 1383 | KAQYTQSKATPLAVR | ubiquitination | [1] | | 1439 | GMYFLDQKERTLLGL | ubiquitination | [1] | | 1582 | LLAMSPEKRKLAAQE | ubiquitination | [1] | | 1851 | TDKVISLKEGDFFFD | ubiquitination | [1] | | 1915 | HYHQELPKYLRGFHK | ubiquitination | [1] | | 1952 | SQLASVSKVLKELVP | ubiquitination | [1] | | 1991 | RKTVAEAKVEFLKYM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia. |
Sequence Annotation | DOMAIN 67 729 Myosin head-like.
DOMAIN 745 765 IQ 1.
DOMAIN 763 792 IQ 2.
DOMAIN 786 815 IQ 3.
DOMAIN 809 838 IQ 4.
DOMAIN 832 861 IQ 5.
DOMAIN 855 884 IQ 6.
DOMAIN 989 1189 MyTH4 1.
DOMAIN 1194 1503 FERM 1.
DOMAIN 1498 1564 SH3 1.
DOMAIN 1606 1670 SH3 2.
DOMAIN 1641 1790 MyTH4 2.
DOMAIN 1790 1896 MyTH4 3.
DOMAIN 1796 2099 FERM 2. |
Keyword | Actin-binding; ATP-binding; Cell membrane; Complete proteome; Membrane; Motor protein; Myosin; Nucleotide-binding; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2113 AA |
Protein Sequence | MSVFRLGDHV WLDPPSSSKT GVAIGGIVKE TKLGKTLIED DEGKEHWVHA EDLSTLRPMH 60
PNSAQGVDDM IRLGDLNEAG VVHNLLIRYQ QHKIYTYTGS ILVAVNPFQM LPLYTLEQVQ 120
IYYSRHMGEL PPHIFAIANS CYFNMKKNKR DQCCIISGES GAGKTETTKL ILQFLATVSG 180
QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIH FNSSGVIEGA SIEHFLLEKS 240
RVCRQAPEER NYHIFYCMLM GMSPEEKQML SLGMPSEYHY LTMGSCTSSE GLSDAKDYAH 300
VRSAMKILQF SDSENWDISK LLAAILHLGN VGFMAAVFEN LDSSDVMETP AFPLAMKLLE 360
VQHQALRDCL IKHTIPVLGE FVSRPVNIAQ ATDRRDAFVK GIYGRLFQWI VKKINAAIFT 420
PQAQDPQNVR RAIGLLDIFG FENFQNNSFE QLCINFANEH LQQFFVKHVF TMEQEEYLSE 480
NITWNYIHYT DNQPILDMLA LKPMSIISLL DEESRFPQGT DVTMLQKLNS IHANNKSFLS 540
PRSIHDTRFG IAHFAGDVYY QAEGFLEKNR DVLSTDILIL IHSSKNKFLK EIFNVDSSQT 600
KLGHGTICQV KAGSQLFKSS DSIKRPVTLA SQFKQSLDQL MRILTNCQPY FVRCIKPNEY 660
KKPLLFDREL CIQQLRYSGM METVHIRKSG FPIRYTFDEF SQRFRVLLPS PERMQFQNKP 720
RQMTLHIADL CLGTDKDWKV GKTKIFLKDH QDTVLEIRRS QALDGAAIRI QRVLRGHKYR 780
KEFLRQRRAA VTLQAGWRGY SQRKNFKLIL VGFERLQAIA RSHLLMRQFQ AMRQRIVQLQ 840
ARCRGYLVRQ QVQAKRRAVV IIQAHARGMV VRKSYWQQKS TGPQVILAKE PKAQVAVHER 900
KRKSIYDTVT DTAMVEKVFG FLPAMIGGQE GPAPTRFEDL EVKTQKLHEV DLDTVPMMAM 960
PEEEVDSLAE YTFPKFAVTY FQKSASHTHI QKPLRYPLLY HENDTDHSAA LDVWIIILRF 1020
MGDLPEPVVY GRNSLTGSSV MRQIHDKLGK DSVTQHNRSS QVASQLNFGE EAFKFDGPIS 1080
DRPMSNLEKV HFIVGYAIMR PGLRDEIYCQ ICKQLSENYK TSSRARGWIL LSLCLGCFPP 1140
SERFMKYLLN FISQGPPSYG PFCAERLQRT FANGVRAEPP TWLELQAVKS KKHIPIQVIL 1200
ATGRSLTISV DSASTSREIC QHVAQKQGLR DNLGFSLQVA VYDKFWSLGS GCDHLMDAVA 1260
QCEQLARERG ESQRQAPWRI YFRKEFFTPW HDSQEDPVST ELIYHQVLRG VWSGEYNFEK 1320
EEELVELLAR HCYVQLGATV KSNAVQELLP SCVPSKLYRT KSPEKWASLV TAAHAKAQYT 1380
QSKATPLAVR EQTVEAARLL WPLLFSRLFE VTTLSGPRLP KTQLVLAINW KGMYFLDQKE 1440
RTLLGLSFAE VMGLVANRDA PGGKKLLLAT LQEEYEFVSP SSVAIAEMVA LFLGGLKERS 1500
VFAMALQDRR ATDDITLLPF KKGDLLILTK KQGLLASENW ALGQNDRTGK TGLVPTACLY 1560
TIPSVTKPST QLLSLLAMSP EKRKLAAQEV RALEPPLEDQ LTESPYTLEE FSYQFFRAPE 1620
KETISRAAMP MARSRGHLWA YSPEPLRQPL LKSVHDKAKL RDAACQIFLA ILKYTGDYPS 1680
RQSWHSLELT DQMFSLALQD PALQDELYCQ ILKQLTHNSI RFSEERAWQL LWLCTGLFPP 1740
GKTLLPHAQK FIDSRKKKPL ALDCSRRLHR VLRVGPRKQP PHDVEVKAAE QNVSKLHHEV 1800
YLPNDTSKSM EVGSSSRVRD LCEGIGTRLQ LASWDGCSLF IKITDKVISL KEGDFFFDSL 1860
RQVSDWVKKN RPQKEGASVT LPYQVFFMRK LWLNVTPGKD VNADTILHYH QELPKYLRGF 1920
HKCSREDAIH LGGLICKIQF GSDSSQLASV SKVLKELVPQ NLTRLMSSEE WKKSLLLECD 1980
KNKRKTVAEA KVEFLKYMYR WPTFGSAFFE VKQTSEPSYP DILLIAINRH GLLLIHPKTK 2040
ELLNTYPFTK ISSWSSGNTY FHMALGSLGQ GSRLLCETSL GYKMDDLLTS YVQQLLNTVN 2100
KQRGFRAPAP ANP 2113 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |