UniProt Accession

 IYD1_RAT; Q5BK17 

Genbank Protein ID

 BC091241 

Genbank Nucleotide ID

 AAH91241.1 

Protein Name

 Iodotyrosine dehalogenase 1 

Protein Synonyms/Alias

 IYD-1 

Gene Name

 Iyd 

Gene Synonyms/Alias

 Dehal1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
254	LGRPSHEKLLVLLPV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). 

Sequence Annotation

 NP_BIND 96 100 FMN (By similarity).
 NP_BIND 123 125 FMN (By similarity).
 NP_BIND 232 235 FMN (By similarity).
 BINDING 100 100 Substrate (By similarity).
 BINDING 157 157 Substrate (By similarity).
 BINDING 178 178 Substrate (By similarity).
 BINDING 275 275 FMN (By similarity).  

Keyword

 Complete proteome; Flavoprotein; FMN; Membrane; NADP; Oxidoreductase; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004447; F:iodide peroxidase activity; IEA:Compara. 

Interpro

 IPR000415; Nitroreductase-like. 

Pfam

 PF00881; Nitroreductase 

SMART

  

PROSITE

  

PRINTS