Tag | Content |
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CPLM ID | CPLM-016831 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATPase WRNIP1 |
Protein Synonyms/Alias | Werner helicase-interacting protein 1 |
Gene Name | Wrnip1 |
Gene Synonyms/Alias | Wrnip |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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70 | GPSPPGAKRRRLSES | acetylation | [1] | 628 | MKDLGYGKGYKYNPM | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). |
Sequence Annotation | ZN_FING 17 40 UBZ-type. NP_BIND 263 270 ATP (Potential). MOD_RES 75 75 Phosphoserine (By similarity). MOD_RES 85 85 Phosphothreonine (By similarity). MOD_RES 91 91 Phosphoserine (By similarity). MOD_RES 92 92 Phosphoserine (By similarity). MOD_RES 116 116 Phosphothreonine (By similarity). MOD_RES 153 153 Phosphoserine (By similarity). MOD_RES 529 529 Phosphotyrosine (By similarity). MOD_RES 557 557 Phosphotyrosine (By similarity). MOD_RES 628 628 N6-acetyllysine; alternate (By CROSSLNK 81 81 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 141 141 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 220 220 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 296 296 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 305 305 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 311 311 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 317 317 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 330 330 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 477 477 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 622 622 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 628 628 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 631 631 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; ATP-binding; Complete proteome; DNA damage; DNA replication; Hydrolase; Isopeptide bond; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 660 AA |
Protein Sequence | MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGPHRAGER 60 AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA 120 RLIPDFPVAR SSSPARKGLG KRPAAAAAAG SASPRSWDET EAQEEEEAGV DGDGDADVDG 180 EDDPGHWDAD AADASFGVSA GRAHPRALPA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA 240 VGQETLLRSL LETNEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV 300 RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA TTENPSFQVN 360 TALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR PTDPLSHSSN CSSEPSVFIE 420 DKAVDTLAYL SDGDARTGLN GLQLAVLARL SSRKMFCKKS GQTYSPSRVL ITENDVKEGL 480 QRSHILYDRA GEEHYNCISA LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE 540 DIGLADPSAL AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR 600 SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR GVDFFKQRRC 660 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006260; P:DNA replication; IEA:UniProtKB-KW. GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB. GO:0030174; P:regulation of DNA-dependent DNA replication initiation; ISS:UniProtKB. |
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