UniProt Accession

 H4_TETTS; P69152; P02311; P02312 

Genbank Protein ID

 X00417; X04755; GG662693; GG662212 

Genbank Nucleotide ID

 CAA25121.1; CAA28452.1; EAR96348.1; EAS07765.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 HHF1; HHF2 

Gene Synonyms/Alias

 TTHERM_00498190; TTHERM_00189170 

Created Date

 July 27, 2013 

Organism

 Tetrahymena thermophila (strain SB210) 

NCBI Taxa ID

 312017 

Lysine Modification

Position	Peptide	Type	References
5	***MAGGKGGKGMGK	acetylation	[1, 2, 3]
8	MAGGKGGKGMGKVGA	acetylation	[1, 2, 3]
12	KGGKGMGKVGAKRHS	acetylation	[1, 2, 3]
16	GMGKVGAKRHSRKSN	acetylation	[1, 2, 3]

Reference

 [1] Amino-acid sequence of Tetrahymena histone H4 differs from that of higher eukaryotes.
 Glover CV, Gorovsky MA.
 Proc Natl Acad Sci U S A. 1979 Feb;76(2):585-9. [PMID: 284382]
 [2] Nonrandom utilization of acetylation sites in histones isolated from Tetrahymena. Evidence for functionally distinct H4 acetylation sites.
 Chicoine LG, Schulman IG, Richman R, Cook RG, Allis CD.
 J Biol Chem. 1986 Jan 25;261(3):1071-6. [PMID: 3080415]
 [3] Organismal differences in post-translational modifications in histones H3 and H4.
 Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Allis CD, Hunt DF.
 J Biol Chem. 2007 Mar 9;282(10):7641-55. [PMID: 17194708] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 16 21
 MOD_RES 5 5 N6-acetyllysine.
 MOD_RES 8 8 N6-acetyllysine.
 MOD_RES 12 12 N6-acetyllysine.
 MOD_RES 16 16 N6-acetyllysine.  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.