CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Frizzled-6 
Protein Synonyms/Alias
 Fz-6; hFz6 
Gene Name
 FZD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
636SGEQVDGKGQAGSVSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. 
Sequence Annotation
 DOMAIN 19 132 FZ.
 MOTIF 498 503 Lys-Thr-X-X-X-Trp motif, mediates
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 352 352 N-linked (GlcNAc...) (Potential).
 DISULFID 24 85 By similarity.
 DISULFID 32 78 By similarity.
 DISULFID 69 106 By similarity.
 DISULFID 95 129 By similarity.
 DISULFID 99 123 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Disease mutation; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 60
FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 120
LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180
CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240
YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 300
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 360
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 480
LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540
KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 600
KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD 660
TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT 706 
Gene Ontology
 GO:0045177; C:apical part of cell; IBA:RefGenome.
 GO:0016327; C:apicolateral plasma membrane; IBA:RefGenome.
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005887; C:integral to plasma membrane; ISS:BHF-UCL.
 GO:0032589; C:neuron projection membrane; IBA:RefGenome.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0030165; F:PDZ domain binding; IBA:RefGenome.
 GO:0042813; F:Wnt-activated receptor activity; IDA:BHF-UCL.
 GO:0017147; F:Wnt-protein binding; ISS:BHF-UCL.
 GO:0001525; P:angiogenesis; IBA:RefGenome.
 GO:0007409; P:axonogenesis; IBA:RefGenome.
 GO:0033278; P:cell proliferation in midbrain; IBA:RefGenome.
 GO:0001736; P:establishment of planar polarity; IBA:RefGenome.
 GO:0007199; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IBA:RefGenome.
 GO:0008406; P:gonad development; IBA:RefGenome.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IBA:RefGenome.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0001843; P:neural tube closure; IBA:RefGenome.
 GO:0035567; P:non-canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0030168; P:platelet activation; IEA:Compara.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara. 
Interpro
 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR020067; Frizzled_dom.
 IPR026543; FZD6.
 IPR017981; GPCR_2-like. 
Pfam
 PF01534; Frizzled
 PF01392; Fz 
SMART
 SM00063; FRI 
PROSITE
 PS50038; FZ
 PS50261; G_PROTEIN_RECEP_F2_4 
PRINTS
 PR00489; FRIZZLED.