UniProt Accession

 GALM_MOUSE; Q8K157 

Genbank Protein ID

 AK040998; BC028818 

Genbank Nucleotide ID

 BAC30776.1; AAH28818.1 

Protein Name

 Aldose 1-epimerase 

Protein Synonyms/Alias

 Galactose mutarotase 

Gene Name

 Galm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	SGGGTVEKFQLRSDQ	acetylation	[1]
21	SGGGTVEKFQLRSDQ	ubiquitination	[2]
51	QVKDRQGKASDVVLG	ubiquitination	[2]
291	NFLDGTLKGKNGAVY	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). 

Sequence Annotation

 REGION 81 82 Substrate binding (By similarity).
 ACT_SITE 176 176 Proton donor (By similarity).
 ACT_SITE 307 307 Proton acceptor (By similarity).
 BINDING 243 243 Substrate (By similarity).  

Keyword

 Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004034; F:aldose 1-epimerase activity; IEA:EC.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR018052; Ald1_epimerase_CS.
 IPR015443; Aldose_1-epimerase.
 IPR008183; Aldose_1/G6P_1-epimerase.
 IPR011013; Gal_mutarotase_SF_dom.
 IPR014718; Glyco_hydro-type_carb-bd_sub. 

Pfam

 PF01263; Aldose_epim 

SMART

  

PROSITE

 PS00545; ALDOSE_1_EPIMERASE 

PRINTS