CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010056
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Arginine--tRNA ligase 
Protein Synonyms/Alias
 Arginyl-tRNA synthetase; ArgRS 
Gene Name
 argS 
Gene Synonyms/Alias
 MPN_556; MP286 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
263KKLLTQFKDEAHYEKacetylation[1]
285TTLYGDDKDRVLVRQacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 MOTIF 113 123 "HIGH" region.  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 537 AA 
Protein Sequence
MLFINTDLQE CLNALNLEFD EHKELVKLVK NNSFSGFAST VVFHLKGVNQ KETAQQIAAW 60
LLKHKKAHYR RVFVANNNFI NFEISPQKYL DFLKTKPTFA PKPTKVLIEW VSANPTGELH 120
LGHVRNAFFG HVLNNLMVFL GFQTVREYWV NDYGQQARVF GFSVYQALHL QQNIKVTPHP 180
DGYEGELVDS IAKTITGIPL DKLSFEEFLQ QPFLDQLLAD CTAKVLEVIK QDLATIHIHF 240
DSWKFESQVV KETDYKKLLT QFKDEAHYEK DGAIWLKTTL YGDDKDRVLV RQDNRPSYFG 300
TDVAYHLDKA ARGFDLLYDI WGSDHEGHIK RMHCVYEGLK IHQKCQLKIT ALQLVMLYKN 360
KEIVRLSKRA GNVITIKQML QMLSEDAARW FMLSQTNNSI IKIDLDTANL QNSSNPVYYV 420
QYAYARMCSV LKVVDQAALA QVNDCSLLTH EKEIALLDQL VYFKSLLEKV QVSHELHLLT 480
NYLYETATLF HSWYKACKIN DPAQYNLTQQ RLLLLQSLHH VFGQLLQILN ITAPQQM 537 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004814; F:arginine-tRNA ligase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0006420; P:arginyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR001278; Arg-tRNA-ligase_Ia.
 IPR015945; Arg-tRNA-synth_Ia_core.
 IPR008909; DALR_anticod-bd.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd. 
Pfam
 PF05746; DALR_1
 PF00750; tRNA-synt_1d 
SMART
 SM00836; DALR_1 
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR01038; TRNASYNTHARG.