CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022153
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GPI mannosyltransferase 2 
Protein Synonyms/Alias
 GPI mannosyltransferase II; GPI-MT-II; Phosphatidylinositol-glycan biosynthesis class V protein; PIG-V 
Gene Name
 PIGV 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
283LVQLAVDKGYRIAEGubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. 
Sequence Annotation
  
Keyword
 Complete proteome; Disease mutation; Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis; Membrane; Mental retardation; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MWPQDPSRKE VLRFAVSCRI LTLMLQALFN AIIPDHHAEA FSPPRLAPSG FVDQLVEGLL 60
GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLVGTE LLRPLRGLLS LRSCLLISVA 120
SLNFLFFMLA AVALHDLGCL VLHCPHQSFY AALLFCLSPA NVFLAAGYSE ALFALLTFSA 180
MGQLERGRVW TSVLLFAFAT GVRSNGLVSV GFLMHSQCQG FFSSLTMLNP LRQLFKLMAS 240
LFLSVFTLGL PFALFQYYAY TQFCLPGSAR PIPEPLVQLA VDKGYRIAEG NEPPWCFWDV 300
PLIYSYIQDV YWNVGFLKYY ELKQVPNFLL AAPVAILVAW ATWTYVTTHP WLCLTLGLQR 360
SKNNKTLEKP DLGFLSPQVF VYVVHAAVLL LFGGLCMHVQ VLTRFLGSST PIMYWFPAHL 420
LQDQEPLLRS LKTVPWKPLA EDSPPGQKVP RNPIMGLLYH WKTCSPVTRY ILGYFLTYWL 480
LGLLLHCNFL PWT 493 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0000030; F:mannosyltransferase activity; IMP:UniProtKB.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. 
Interpro
 IPR007315; GPI_Mannosyltransferase_2. 
Pfam
 PF04188; Mannosyl_trans2 
SMART
  
PROSITE
  
PRINTS