CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014510
UniProt Accession
Genbank Protein ID
 X74800 
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-Ic 
Protein Synonyms/Alias
 Myosin I beta; MMI-beta; MMIb; Myosin heavy chain myr 2 
Gene Name
 Myo1c 
Gene Synonyms/Alias
 Myr2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
205ILSYLLEKSRVVHQNacetylation[1]
266INDKSDWKVVRKALSacetylation[1]
467ICDLVEEKFKGIISIacetylation[1]
499EKLEDTIKHHPHFLTacetylation[1]
508HPHFLTHKLADQKTRacetylation[1]
648AGFAYRRKYEAFLQRacetylation[1]
685LVRHLGYKPEEYKMGacetylation[1]
690GYKPEEYKMGRTKIFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). 
Sequence Annotation
 DOMAIN 17 699 Myosin head-like.
 DOMAIN 715 744 IQ 1.
 DOMAIN 738 767 IQ 2.
 NP_BIND 121 128 ATP (Potential).
 MOD_RES 364 364 N6-methyllysine (By similarity).
 MOD_RES 389 389 Phosphoserine (By similarity).  
Keyword
 Actin-binding; ATP-binding; Calmodulin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Membrane; Methylation; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1044 AA 
Protein Sequence
MRYRASALGS DGVRVTMESA LTARDRVGVQ DFVLLENFTS EAAFIENLRR RFRENLIYTY 60
IGPVLVSVNP YRDLQIYTRQ HMERYRGVSF YEVPPHLFAV ADTVYRALRT ERRDQAVMIS 120
GESGAGKTEA TKRLLQFYAE TCPAPERGGA VRDRLLQSNP VLEAFGNAKT LRNDNSSRFG 180
KYMDVQFDFK GAPVGGHILS YLLEKSRVVH QNHGERNFHV FYQLLEGGEE EALRRLGLER 240
NPQSYLYLVK GQCAKVSSIN DKSDWKVVRK ALSVIDFTED EVEDLLSIVA SVLHLGNIHF 300
AADEDSNAQV TTENQLKYLT RLLGVEGTTL REALTHRKII AKGEELLSPL NLEQAAYARD 360
ALAKAVYSRT FTWLVRKINR SLASKDAESP SWRSTTVLGL LDIYGFEVFQ HNSFEQFCIN 420
YCNEKLQQLF IELTLKSEQE EYEAEGIAWE PVQYFNNKII CDLVEEKFKG IISILDEECL 480
RPGEATDLTF LEKLEDTIKH HPHFLTHKLA DQKTRKSLDR GEFRLLHYAG EVTYSVTGFL 540
DKNNDLLFRN LKETMCSSTN PIMAQCFDKS ELSDKKRPET VATQFKMSLL QLVEILRSKE 600
PAYIRCIKPN DAKQPGRFDE VLIRHQVKYL GLMENLRVRR AGFAYRRKYE AFLQRYKSLC 660
PETWPVWTGR PQDGVAVLVR HLGYKPEEYK MGRTKIFIRF PKTLFATEDS LEVRRQSLAT 720
KIQAAWRGFH WRQKFLRVKR SAICIQSWWR GTLGRRKAAK RKWAAQTIRR LIRGFILRHA 780
PRCPENAFFL DHVRTSFLLN LRRQLPRNVL DTSWPTPPPA LREASELLRE LCMKNMVWKY 840
CRSISPEWKQ QLQQKAVASE IFKGKKDNYP QSVPRLFIST RLGTEEISPR VLQALGSEPI 900
QYAVPVVKYD RKGYKPRSRQ LLLTPSAVVI VEDAKVKQRI DYANLTGISV SSLSDSLFVL 960
HVQREDSKQK GDVVLQSDHV IETLTKTALS ADRVNNININ QGSITFAGGP GRDGIIDFTS 1020
GSELLITKAK NGHLAVVAPR LNSR 1044 
Gene Ontology
 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0005903; C:brush border; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0031941; C:filamentous actin; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0045160; C:myosin I complex; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0038089; P:positive regulation of cell migration by vascular endothelial growth factor signaling pathway; IEA:Compara.
 GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Compara.
 GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Compara.
 GO:0006612; P:protein targeting to membrane; IEA:Compara.
 GO:2000810; P:regulation of tight junction assembly; IEA:Compara. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR010926; Myosin_tail_2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF06017; Myosin_TH1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.