CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036790
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein LYRIC 
Protein Synonyms/Alias
  
Gene Name
 MTDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84PDDLALLKNLRSEEQubiquitination[1, 2, 3, 4]
127TPQSVTAKQPPEIDKubiquitination[2]
151KKSKSDAKAVQNSSRubiquitination[2]
162NSSRHDGKEVDEGAWubiquitination[2, 3, 5]
172DEGAWETKISHREKRubiquitination[3]
435QEKAFSLKTISTSDPubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MLSVGLGFLR TELGLDLGLE PKRYPGWVIL VGTGALGLLL LFLLGYGWAA ACAGARKKRR 60
SPPRKREEAA AVPAAAPDDL ALLKNLRSEE QKKKNRKKLS EKPKPNGRTV EVAEGEAVRT 120
PQSVTAKQPP EIDKKNEKSK KNKKKSKSDA KAVQNSSRHD GKEVDEGAWE TKISHREKRQ 180
QRKRDKVLTD SGSLDSTIPG IENTITVTTE QLTTASFPVG SKKNKGDSHL NVQVSNFKSG 240
KGDSTLQVSS GLNENLTVNG GGWNEKSVKL SSQISAGEEK WNSVSPASAG KRKTEPSAWS 300
QDTGDANTNG KDWGRSWSDR SIFSGIDGLS SADPNSDWNA PAEEWGNWVD EERASLLKSQ 360
EPIPDDQKVS DDDKEKGEGA LPTGKSKKKK KKKKKQGEDN STAQDTEELE KEIREDLPVN 420
TSKTRPKQEK AFSLKTISTS DPAEVLVKNS QPIKTLPPAT STEPSVILSK SDSDKSSSQV 480
PPILQETDKS KSNTKQNSVP PSQTKSETSW ESPKQIKKKK KARRET 526 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS