UniProt Accession

 STMN1_RAT; P13668 

Genbank Protein ID

 J04979; M27876; X94914; BC062234 

Genbank Nucleotide ID

 AAA42184.1; AAA81570.1; CAA64400.1; AAH62234.1 

Protein Name

 Stathmin 

Protein Synonyms/Alias

 Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Pr22 protein; Prosolin; pp17 

Gene Name

 Stmn1 

Gene Synonyms/Alias

 Lap18 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
9	ASSDIQVKELEKRAS	acetylation	[1]
52	LSLEEIQKKLEAAEE	ubiquitination	[2]
80	AEKREHEKEVLQKAI	ubiquitination	[2]
85	HEKEVLQKAIEENNN	acetylation	[1]
95	EENNNFSKMAEEKLT	acetylation	[1]
100	FSKMAEEKLTHKMEA	acetylation	[1]
104	AEEKLTHKMEANKEN	acetylation	[1]
119	REAQMAAKLERLREK	acetylation	[1]
119	REAQMAAKLERLREK	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). 

Sequence Annotation

 DOMAIN 4 145 SLD.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 25 25 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 31 31 Phosphoserine (By similarity).
 MOD_RES 38 38 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 46 46 Phosphoserine (By similarity).
 MOD_RES 63 63 Phosphoserine; by PKA (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 100 100 N6-acetyllysine (By similarity).
 MOD_RES 119 119 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; TAS:RGD.
 GO:0007019; P:microtubule depolymerization; TAS:RGD.
 GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:InterPro. 

Interpro

 IPR000956; Stathmin_fam. 

Pfam

 PF00836; Stathmin 

SMART

  

PROSITE

 PS00563; STATHMIN_1
 PS01041; STATHMIN_2
 PS51663; STATHMIN_3 

PRINTS

 PR00345; STATHMIN.