CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine--tRNA ligase 
Protein Synonyms/Alias
 Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase 
Gene Name
 serS 
Gene Synonyms/Alias
 STM0963 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
24KLARRGFKLDVDKLRacetylation[1]
29GFKLDVDKLRALEERacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity). 
Sequence Annotation
 NP_BIND 268 270 ATP (By similarity).
 NP_BIND 355 358 ATP (By similarity).
 REGION 237 239 Serine binding (By similarity).
 BINDING 291 291 Serine (By similarity).
 BINDING 391 391 Serine (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 430 AA 
Protein Sequence
MLDPNLLRNE PDAVAEKLAR RGFKLDVDKL RALEERRKVL QVNTENLQAE RNSRSKSIGQ 60
AKARGEDIEP LRLEVNKLGE ELDAAKAELD TLLAEIRDIA LTIPNLPADE VPVGKDENDN 120
VEVSRWGTPR EFDFEIRDHV TLGEMHSGLD FAAAVKLTGS RFVVMKGQIA RMHRALSQFM 180
LDLHTEQHGY SENYVPYLVN HDTLYGTGQL PKFAGDLFHT RPLEEEADSS NYALIPTAEV 240
PLTNLVRDEI IDEDQLPIKM TAHTPCFRSE AGSYGRDTRG LIRMHQFDKV EMVQIVRPED 300
SMAALEEMTG HAEKVLQLLG LPYRKIILCT GDMGFGACKT YDLEVWVPAQ NTYREISSCS 360
NVWDFQARRM QARCRSKSDK KTRLVHTLNG SGLAVGRTLV AVMENYQQAD GRIEVPEVLR 420
PYMNGLEYIG 430 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004828; F:serine-tRNA ligase activity; IEA:HAMAP.
 GO:0016260; P:selenocysteine biosynthetic process; IEA:HAMAP.
 GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006434; P:seryl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR002317; Ser-tRNA-ligase_type_1.
 IPR015866; Ser-tRNA-synth_1_N.
 IPR010978; tRNA-bd_arm. 
Pfam
 PF02403; Seryl_tRNA_N
 PF00587; tRNA-synt_2b 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00981; TRNASYNTHSER.