| Tag | Content |
|---|
| CPLM ID | CPLM-006549 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein phosphatase non-receptor type 12 |
Protein Synonyms/Alias | MPTP-PEST; Protein-tyrosine phosphatase P19; P19-PTP |
Gene Name | Ptpn12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 296 | AIAQLFEKQLQLYEI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 (By similarity). |
Sequence Annotation | DOMAIN 28 293 Tyrosine-protein phosphatase.
REGION 231 237 Substrate binding (By similarity).
REGION 344 437 Interaction with TGFB1I1.
ACT_SITE 231 231 Phosphocysteine intermediate (By
BINDING 199 199 Substrate (By similarity).
BINDING 278 278 Substrate (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 19 19 Phosphoserine (By similarity).
MOD_RES 186 186 Phosphoserine.
MOD_RES 331 331 Phosphoserine.
MOD_RES 434 434 Phosphoserine.
MOD_RES 448 448 Phosphoserine (By similarity).
MOD_RES 467 467 Phosphoserine (By similarity).
MOD_RES 519 519 Phosphothreonine (By similarity).
MOD_RES 567 567 Phosphoserine (By similarity).
MOD_RES 569 569 Phosphothreonine (By similarity).
MOD_RES 596 596 Phosphoserine.
MOD_RES 598 598 Phosphothreonine.
MOD_RES 603 603 Phosphoserine.
MOD_RES 606 606 Phosphoserine (By similarity).
MOD_RES 608 608 Phosphoserine.
MOD_RES 613 613 Phosphoserine (By similarity).
MOD_RES 673 673 Phosphoserine.
MOD_RES 748 748 Phosphoserine. |
Keyword | Acetylation; Cell junction; Cell projection; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 775 AA |
Protein Sequence | MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK 60
KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM 120
IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCENEQAR TDYFIRTLLL 180
EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA 240
ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL 300
YEIHGAQKIA DGNEITTGTM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE EILQPPEPHP 360
VPPILTPSPP SAFPTVTTVW QDSDRYHPKP VLHMASPEQH PADLNRSYDK SADPMGKSES 420
AIEHIDKKLE RNLSFEIKKV PLQEGPKSFD GNTLLNRGHA IKIKSASSSV VDRTSKPQEL 480
SAGALKVDDV SQNSCADCSA AHSHRAAESS EESQSNSHTP PRPDCLPLDK KGHVTWSLHG 540
PENATPVPDS PDGKSPDNHS QTLKTVSSTP NSTAEEEAHD LTEHHNSSPL LKAPLSFTNP 600
LHSDDSDSDG GSSDGAVTRN KTSISTASAT VSPASSAESA CTRRVLPMSI ARQEVAGTPH 660
SGAEKDADVS EESPPPLPER TPESFVLADM PVRPEWHELP NQEWSEQRES EGLTTSGNEK 720
HDAGGIHTEA SADSPPAFSD KKDQITKSPA EVTDIGFGNR CGKPKGPREP PSEWT 775 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |