UniProt Accession

 MFNG_HUMAN; O00587; B4DLT6; O43730; Q504S9 

Genbank Protein ID

 U94352; CR456518; AK297149; Z93096; BC094814 

Genbank Nucleotide ID

 AAC51358.1; CAG30404.1; BAG59648.1; CAB07511.1; AAH94814.1 

Protein Name

 Beta-1,3-N-acetylglucosaminyltransferase manic fringe 

Protein Synonyms/Alias

 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 

Gene Name

 MFNG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
210	INRKLALKMAPWASG	ubiquitination	[1]
242	MGYIIECKLGGRLQP	ubiquitination	[1]
287	EGKLNVIKLQGPFSP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. 

Sequence Annotation

 ACT_SITE 232 232 By similarity.
 METAL 144 144 Manganese (By similarity).
 METAL 256 256 Manganese (By similarity).
 BINDING 70 70 Substrate (By similarity).
 BINDING 143 143 Substrate (By similarity).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 185 185 N-linked (GlcNAc...) (Potential).
 DISULFID 110 121 By similarity.
 DISULFID 139 202 By similarity.
 DISULFID 306 315 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Manganese; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0030173; C:integral to Golgi membrane; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0033829; F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; IEA:EC.
 GO:0007389; P:pattern specification process; TAS:ProtInc.
 GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara. 

Interpro

 IPR017374; Fringe.
 IPR003378; Fringe-like. 

Pfam

 PF02434; Fringe 

SMART

  

PROSITE

  

PRINTS