UniProt Accession

 ATF3_HUMAN; P18847; Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6 

Genbank Protein ID

 L19871; AB066566; AB078026; AB078027; AY313927; BT006996; AY426987; AK312998; DA589280; CR450334; AC092803; AL590648; AL590648; AL590648; AL606913; CH471100; CH471100; CH471100; CH471100; BC006322 

Genbank Nucleotide ID

 AAA20506.1; BAB84092.1; BAC00495.1; BAC00496.1; AAP93896.1; AAP35642.1; AAQ93358.1; BAG35834.1; CAG29330.1; CAH72653.1; CAH72654.1; CAH72656.1; EAW93385.1; EAW93386.1; EAW93387.1; EAW93388.1; AAH06322.1 

Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 

Protein Synonyms/Alias

 cAMP-dependent transcription factor ATF-3; Activating transcription factor 3 

Gene Name

 ATF3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
175	NLFIQQIKEGTLQS*	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. 

Sequence Annotation

 DOMAIN 86 149 bZIP.
 REGION 88 110 Basic motif (By similarity).
 REGION 114 142 Leucine-zipper (By similarity).  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006094; P:gluconeogenesis; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS

 PR00042; LEUZIPPRFOS.