UniProt Accession

 CEBPA_MOUSE; P53566; Q91XB6 

Genbank Protein ID

 M62362; BC011118; BC028890; BC051102; BC058161 

Genbank Nucleotide ID

 AAA37374.1; AAH11118.1; AAH28890.1; AAH51102.1; AAH58161.1 

Protein Name

 CCAAT/enhancer-binding protein alpha 

Protein Synonyms/Alias

 C/EBP alpha 

Gene Name

 Cebpa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
159	ALRPLVIKQEPREED	sumoylation	[1, 2]

Reference

 [1] Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
 Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC.
 J Biol Chem. 2002 Oct 11;277(41):38037-44. [PMID: 12161447]
 [2] Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part, to aberrant C/EBPα activity in acute leukemias.
 Hankey W, Silver M, Sun BS, Zibello T, Berliner N, Khanna-Gupta A.
 Hematol Rep. 2011 Jan 13;3(1):e5. [PMID: 22184527] 

Functional Description

 C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. 

Sequence Annotation

 DOMAIN 283 346 bZIP.
 REGION 287 314 Basic motif (By similarity).
 REGION 318 346 Leucine-zipper (By similarity).
 MOD_RES 159 159 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0035189; C:Rb-E2F complex; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0006953; P:acute-phase response; IEA:Compara.
 GO:0050873; P:brown fat cell differentiation; IDA:MGI.
 GO:0048469; P:cell maturation; IMP:MGI.
 GO:0071285; P:cellular response to lithium ion; IDA:MGI.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
 GO:0001892; P:embryonic placenta development; IGI:MGI.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0030225; P:macrophage differentiation; IMP:MGI.
 GO:0007005; P:mitochondrion organization; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0045600; P:positive regulation of fat cell differentiation; IDA:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0033274; P:response to vitamin B2; IEA:Compara.
 GO:0000050; P:urea cycle; IDA:MGI.
 GO:0050872; P:white fat cell differentiation; IMP:MGI. 

Interpro

 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS