| Tag | Content |
|---|
| CPLM ID | CPLM-024598 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 |
Protein Synonyms/Alias | E-NPP 6; NPP-6; Choline-specific glycerophosphodiester phosphodiesterase; Glycerophosphocholine cholinephosphodiesterase; GPC-Cpde |
Gene Name | Enpp6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 289 | KHSEIYHKLRTVEHM | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid (By similarity). |
Sequence Annotation | ACT_SITE 71 71 Potential.
LIPID 419 419 GPI-anchor amidated serine (Potential).
CARBOHYD 100 100 N-linked (GlcNAc...) (By similarity).
CARBOHYD 118 118 N-linked (GlcNAc...) (By similarity).
CARBOHYD 341 341 N-linked (GlcNAc...) (By similarity).
CARBOHYD 404 404 N-linked (GlcNAc...) (By similarity).
DISULFID 142 154 By similarity.
DISULFID 412 412 Interchain (By similarity). |
Keyword | Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Hydrolase; Lipid degradation; Lipid metabolism; Lipoprotein; Membrane; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 440 AA |
Protein Sequence | MAGKLWTFLL LFGFSWVWPA SAHRKLLVLL LDGFRSDYIS EDALASLPGF REIVNRGVKV 60
DYLTPDFPSL SYPNYYTLMT GRHCEVHQMI GNYMWDPRTN KSFDIGVNRD SLMPLWWNGS 120
EPLWITLMKA RRKVYMYYWP GCEVEILGVR PTYCLEYKNV PTDINFANAV SDALDSLKSG 180
RADLAAIYHE RIDVEGHHYG PSSPQRKDAL KAVDTVLKYM TQWIQERGLQ NDLNVILFSD 240
HGMTDIFWMD KVIELSKYIS LDDLQQVKDQ GPVVSLWPVP EKHSEIYHKL RTVEHMTVYE 300
KEAIPNRFYY KKGKFVSPLT LVADEGWFIA ESREALPFWM NSTGKREGWQ HGWHGYDNEL 360
MDMRGIFLAF GPDFKSNFRA APIRSVDVYN IMCNVVGITP LPNNGSWSRV VCMLKSQTSS 420
SPSIPPNSCA LVLILLLYFV 440 |
Gene Ontology | GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW. GO:0005576; C:extracellular region; IEA:Compara. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0047390; F:glycerophosphocholine cholinephosphodiesterase activity; ISS:UniProtKB. GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:Compara. GO:0019695; P:choline metabolic process; ISS:UniProtKB. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0006629; P:lipid metabolic process; ISS:UniProtKB. |
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