CPLM-009431

Genbank Nucleotide ID

Protein Synonyms/Alias

Calm; Cam; Cam1; Cam2; Camb; Cam3; Camc

Rattus norvegicus (Rat)

Position	Peptide	Type	References
22	EAFSLFDKDGDGTIT	ubiquitination	[1]
31	GDGTITTKELGTVMR	ubiquitination	[1]
78	TMMARKMKDTDSEEE	acetylation	[2]
95	EAFRVFDKDGNGYIS	ubiquitination	[1]

[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
[2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).

DOMAIN 8 43 EF-hand 1.
DOMAIN 44 79 EF-hand 2.
DOMAIN 81 116 EF-hand 3.
DOMAIN 117 149 EF-hand 4.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 22 22 N6-acetyllysine; alternate (By
MOD_RES 45 45 Phosphothreonine; by CaMK4.
MOD_RES 95 95 N6-acetyllysine (By similarity).
MOD_RES 100 100 Phosphotyrosine (By similarity).
MOD_RES 102 102 Phosphoserine (By similarity).
MOD_RES 116 116 N6,N6,N6-trimethyllysine.
MOD_RES 139 139 Phosphotyrosine (By similarity).
CROSSLNK 22 22 Glycyl lysine isopeptide (Lys-Gly)

3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Metal-binding; Methylation; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005813; C:centrosome; IEA:Compara.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030426; C:growth cone; IDA:RGD.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005886; C:plasma membrane; IDA:RGD.
GO:0005876; C:spindle microtubule; IEA:Compara.
GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0008179; F:adenylate cyclase binding; IDA:RGD.
GO:0005246; F:calcium channel regulator activity; NAS:RGD.
GO:0005509; F:calcium ion binding; IDA:RGD.
GO:0044325; F:ion channel binding; IDA:RGD.
GO:0050998; F:nitric-oxide synthase binding; IDA:RGD.
GO:0030235; F:nitric-oxide synthase regulator activity; IDA:RGD.
GO:0047485; F:protein N-terminus binding; IMP:RGD.
GO:0007190; P:activation of adenylate cyclase activity; IDA:RGD.
GO:0019722; P:calcium-mediated signaling; IMP:RGD.
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:RGD.
GO:0032465; P:regulation of cytokinesis; IEA:Compara.
GO:1901841; P:regulation of high voltage-gated calcium channel activity; IMP:RGD.
GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IDA:RGD.
GO:1901339; P:regulation of store-operated calcium channel activity; IC:RGD.
GO:0001975; P:response to amphetamine; IEP:RGD.
GO:0051592; P:response to calcium ion; IEA:Compara.
GO:0051412; P:response to corticosterone stimulus; IEP:RGD.

IPR011992; EF-hand-like_dom.
IPR018247; EF_Hand_1_Ca_BS.
IPR002048; EF_hand_dom.
IPR001125; Recoverin.

PS00018; EF_HAND_1
PS50222; EF_HAND_2